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SKIN AGING

Niche stiffness regulates stem cell aging

Nature Aging volume 2, pages 568–569 (2022)Cite this article

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The microenvironment can regulate adult stem cell function during tissue homeostasis and regeneration, but whether and how this is altered in aging is unclear. Ichijo et al. find that increased dermal stiffness, as a result of vasculature atrophy, activates cation channel PIEZO1, leading to interfollicular epidermal stem cell dysregulation.

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Fig. 1: Interfollicular epidermal stem cell (IFESC) aging.

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Authors and Affiliations

  1. The Ronald O. Perelman Department of Dermatology, New York University, School of Medicine, New York, NY, USA

    Chae Ho Lim & Mayumi Ito

  2. Department of Cell Biology, New York University, School of Medicine, New York, NY, USA

    Chae Ho Lim & Mayumi Ito

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  1. Chae Ho Lim
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  2. Mayumi Ito
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Correspondence to Chae Ho Lim or Mayumi Ito.

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The authors declare no competing interests.

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Lim, C.H., Ito, M. Niche stiffness regulates stem cell aging. Nat Aging 2, 568–569 (2022). https://doi.org/10.1038/s43587-022-00259-z

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