Muscle function decreases with age, and there are few preventative treatments. Zhang et al. find that different cell types in aging muscle express different senescence markers, giving insight into the complexity of senescence biology. They also show that aspects of muscle aging can be improved with senotherapeutic intervention.
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Acknowledgements
Work in the Keyes lab was supported in part by grants from La Fondation pour la Recherche Medicale (FRM) (AJE20160635985), Fondation ARC pour la Recherche sur le Cancer (PJA20181208104), La Fondation Schlumberger pour l’Education et la Recherche (FSER 19 (Year 2018)/FRM), and Agence Nationale de la Recherche (ANR) (ANR-19-CE13-0023-03).
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M.D. owns shares in Unity Biotechnology. W.M.K. declares no competing interests.
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Durik, M., Keyes, W.M. Senescence diversity in muscle aging. Nat Aging 2, 570–572 (2022). https://doi.org/10.1038/s43587-022-00255-3
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DOI: https://doi.org/10.1038/s43587-022-00255-3
