Compromised clearance of dysfunctional mitochondria, through the process of mitophagy, has garnered attention as an essential contributor to aging and neurodegeneration. Schmid and colleagues1 reveal that genetic enhancement of mitophagy via neuronal overexpression of BNIP3 alleviates brain aging and prolongs healthspan in fruit flies.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schmid, E. T., Pyo, J.-H. & Walker, D. W. Nat. Aging https://doi.org/10.1038/s43587-022-00214-y (2022).
Fang, E. F. et al. Nat. Neurosci. 22, 401–412 (2019).
Lautrup, S., Sinclair, D. A., Mattson, M. P. & Fang, E. F. Cell Metab. 30, 630–655 (2019).
Palikaras, K., Lionaki, E. & Tavernarakis, N. Nature 521, 525–528 (2015).
Aman, Y. et al. Nat Aging 1, 634–650 (2021).
Hanna, R. A. et al. J. Biol. Chem. 287, 19094–19104 (2012).
Zhu, Y. et al. J. Biol. Chem. 288, 1099–1113 (2013).
Zhang, T. et al. J. Biol. Chem. 291, 21616–21629 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
E.F.F. has a CRADA arrangement with ChromaDex (USA) and is consultant to Aladdin Healthcare Technologies (UK and Germany), the Vancouver Dementia Prevention Centre (Canada), Intellectual Labs (Norway) and MindRank AI (China).
Rights and permissions
About this article
Cite this article
Lautrup, S., Fang, E.F. Enhanced brain mitophagy slows systemic aging. Nat Aging 2, 463–464 (2022). https://doi.org/10.1038/s43587-022-00226-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-022-00226-8