Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DIET AND HEALTH

Nutrition’s dark matter of polyphenols and health

Food contains thousands of different trace natural compounds, many of which remain largely unmeasured and undocumented. The network medicine approach sheds new light on how polyphenols, among the most important of these trace compounds, impact human health.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The impacts on human health of flavonoids, phenolic acids, phenolic amides, and other polyphenols found in foods are largely unexplored, and may benefit from a network medicine approach.

References

  1. Wang, D. D. et al. J. Nutr. 149, 1065–1074 (2019).

    Article  Google Scholar 

  2. Scotece, M. et al. Drug Discov. Today 20, 406–410 (2015).

    Article  CAS  Google Scholar 

  3. Mozaffarian, D. & Wu, J. H. Y. Circ. Res. 122, 369–384 (2018).

    Article  CAS  Google Scholar 

  4. do Valle, I. F. et al. Nat. Food https://doi.org/10.1038/s43016-021-00243-7 (2021).

  5. Kawser Hossain, M. et al. Int. J. Mol. Sci. 17, 569 (2016).

    Article  Google Scholar 

  6. Warner, E. F. et al. J. Nutr. 146, 465–473 (2016).

    Article  CAS  Google Scholar 

  7. Cassidy, A. & Minihane, A. M. Am. J. Clin. Nutr. 105, 10–22 (2017).

    Article  CAS  Google Scholar 

  8. Goya, L. et al. Nutrients 8, 212 (2016).

    Article  Google Scholar 

  9. Fleischhacker, S. E. et al. Am. J. Clin. Nutr. 112, 721–769 (2020).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dariush Mozaffarian.

Ethics declarations

Competing interests

This work was supported by the National Institutes of Health (R01 HL115189). The author also reports, outside of this work, research support from the Gates Foundation and the Rockefeller Foundation; personal fees from Acasti Pharma, Amarin, America’s Test Kitchen, Barilla, Cleveland Clinic Foundation, Danone, GOED, and Motif FoodWorks; scientific advisory board, Beren Therapeutics, Brightseed, Calibrate, DayTwo, Elysium Health, Filtricine, Foodome, HumanCo, January Inc., and Tiny Organics; and chapter royalties from UpToDate.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mozaffarian, D. Nutrition’s dark matter of polyphenols and health. Nat Food 2, 139–140 (2021). https://doi.org/10.1038/s43016-021-00248-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43016-021-00248-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing