Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion, food intake and gut motility. GLP-1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed. Here, we provide a concise overview of the core physiology of GLP-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
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Research in the laboratories of F.M.G. and F.R. is primarily supported by Wellcome (106262/Z/14/Z and 106263/Z/14/Z) and MRC-UK (MRC_MC_UU_12012/3) funding.
F.M.G. is a consultant for Kallyope, and the laboratories of F.M.G. and F.R. receive additional research funding from AstraZeneca, Eli Lilly and LGC.
Peer review information Primary Handling Editor: Christoph Schmitt. Nature Metabolism thanks Brian Finan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Gribble, F.M., Reimann, F. Metabolic Messengers: glucagon-like peptide 1. Nat Metab (2021). https://doi.org/10.1038/s42255-020-00327-x