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Stressing the other paraventricular nucleus

Often overlooked, the paraventricular nucleus of the thalamus is a stress-sensitive region in the midline thalamus essential for stress-induced adaptations. Using cutting edge in vivo monitoring approaches, Beas, Wright et al. identify a circuit by which stress disinhibits the midline thalamus through dopaminergic modulation arising from the locus coeruleus.

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Fig. 1: Translation of stress to motivation circuitry.


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Correspondence to Kurt M. Fraser or Patricia H. Janak.

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Fraser, K.M., Janak, P.H. Stressing the other paraventricular nucleus. Nat Neurosci 21, 901–902 (2018).

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