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The association between connectivity of the hypothalamus and stress is not well understood. Here, the authors show connectivity between hypothalamic nuclei and other subcortical structures is predictive of stress.
Significant aversive experience can cause lasting behavioral changes due to shifts in arousal thresholds and filter mechanisms. Here, in male mice, the authors identify a change in a neural circuit, underlying adversity driven enhanced threat response.
Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.
Two articles in Nature Reviews Psychology propose a resilience-based approach to mental health outcomes that shifts attention from a binary view of psychopathology to diversity.