pA regulator is an RNA-based, non-immunogenic regulation system of gene expression that achieves up to 900-fold induction by using an inducer drug within the clinically safe dose range.
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This is a summary of: Luo, L., Jea, J. D.-Y., Wang, Y., Chao, P.-W. & Yen, L. Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01989-0 (2024).
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A step closer to safe and efficient mammalian gene regulation. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02020-2
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DOI: https://doi.org/10.1038/s41587-023-02020-2
