Correction to: Nature https://doi.org/10.1038/s41586-021-03345-1 Published online 10 March 2021

In the version of this article initially published, there was a plotting error affecting Fig. 1d,e and Extended Data Fig. 1b. SBS signature extraction was performed for the bulk placental samples on a per-placenta basis, but the results were plotted on a per-sample basis, duplicating the signature proportion estimates where multi-regional sampling was done. The error does not affect the conclusions reported in the paper.

Fig. 1: Incorrect and corrected Fig.
figure 1

1d,e.

Full size image
Fig. 2: Incorrect and corrected Extended Data Fig.
figure 2

1b.

Full size image

In Fig. 1d caption, the text originally reading “SBS signatures in placental biopsies. Each column represents one bulk sample,” has been amended to read “SBS signatures in placentas that underwent bulk sampling. Each column represents the unique substitutions across one placenta (n = 36, placenta from trisomic rescue case not included).” The Fig. 1e caption, originally beginning “Prevalence of SBS18 mutations in bulk placental biopsies,” has been amended to read “Prevalence of SBS18 mutations across each placenta that underwent bulk sampling.”

In Extended Data Fig. 1b caption, the text originally reading “Mutational signature profiles of each bulk placental sample by their clinical group. Each bar represents a single bulk placental sample,” has been amended to read “Mutational signature profiles of each placenta by their clinical group (n = 36, placenta from trisomic rescue case not included). Each column represents one placenta (signature extraction performed across all unique substitutions per placenta in view of their low individual mutation burdens).”

The original and corrected Fig. 1d,e and Extended Data Fig. 1b are shown above.

The changes have been made to the online version of the article.