Findings from a multi-cohort analysis indicate that levels of neutrophil extracellular trap (NET) remnants are elevated in paediatric patients affected by multi-system inflammatory syndrome in children or chilblain-like lesions (also known as ‘COVID toes’), as well as in adults with symptomatic COVID-19, and were associated with clinical outcomes. Impaired NET degradation was observed in both adult and paediatric populations; these impairments did not seem to be genetically driven and were considered to be multifactorial.
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Carmona-Rivera, C. et al. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19. JCI Insight https://doi.org/10.1172/jci.insight.160332 (2022)
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Onuora, S. NETs implicated in COVID-19 in kids and adults. Nat Rev Rheumatol 18, 552 (2022). https://doi.org/10.1038/s41584-022-00830-3
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DOI: https://doi.org/10.1038/s41584-022-00830-3