After administration of a third dose of mRNA vaccine, mean cross-neutralizing antibody responses against the Omicron variant of SARS-CoV-2 were 50.3% in health-care workers but only 26.8% in patients with autoimmune rheumatic diseases (ARDs) in an observational cohort study. Responses capable of neutralizing the Omicron variant were detected in only 39.2% of sera from patients with ARDs who received a third dose of mRNA vaccine. Among the 19 patients with ARDs with confirmed breakthrough infections in the subsequent observation period, 14 (73.7%) had not reached the Omicron-neutralization capacity threshold pre-infection.
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Kim, W.-J. et al. SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study. Ann. Rheum. Dis. https://doi.org/10.1136/ard-2022-222689 (2022)
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Onuora, S. Omicron evades immunity from vaccines. Nat Rev Rheumatol 18, 552 (2022). https://doi.org/10.1038/s41584-022-00829-w
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DOI: https://doi.org/10.1038/s41584-022-00829-w