In a study of 640 patients with psoriatic arthritis (PsA) from 13 countries, 37.7% reported severe pain and 45.6% reported severe fatigue after more than 3 months of treatment with TNF inhibitors, suggesting a need for improved disease management in PsA. Health-related quality of life and work productivity scores were worse in patients with moderate or severe pain or fatigue compared with those with low pain or fatigue. Mental health scores (self-reported happiness and the mental health domain of short form-36 v2) were also lowest in patients reporting the most severe pain or fatigue.