Analysis of data on 4,796 participants from the Osteoarthritis Initiative has revealed an increased risk in all-cause mortality in individuals with knee osteoarthritis (OA). Compared with individuals with no knee pain and no radiographic knee OA, individuals with symptomatic knee OA (pain and radiographic progression) had a hazard ratio (HR) for mortality of 2.2 (95% CI 1.6–3.1), whereas those with radiographic OA had an HR of 2.0 (95% CI 1.4–2.9), and those with knee pain only had an HR of 0.9 (95% CI 0.6–1.4). Disability and changes in quality of life related to OA partly contributed to the increase in mortality.
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Wang, Y. et al. Knee osteoarthritis, potential mediators, and risk of all-cause mortality: data from the Osteoarthritis Initiative. Arthritis Care Res. https://doi.org/10.1002/acr.24151 (2020)
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Clarke, J. Knee OA increases risk of all-cause mortality. Nat Rev Rheumatol 16, 126 (2020). https://doi.org/10.1038/s41584-020-0381-9
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DOI: https://doi.org/10.1038/s41584-020-0381-9
