The immunoregulatory cytokine IL-41 (also known as meteorin-like protein) is expressed at high levels in the synovium of patients with psoriatic arthritis (PsA), compared with patients with osteoarthritis (OA). IL-41 is also present at the enthesis, the primary inflammatory site of PsA, where it is produced primarily by entheseal stromal cells. Expression of IL-41 by entheseal stromal cells can be further induced by stimulation with IL-17A/F and TNF. The functional effects of IL-41 in psoriatic inflammation remain unclear.
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Bridgewood, C. et al. The novel cytokine Metrnl/IL-41 is elevated in psoriatic arthritis synovium and induced at the enthesis. Clin. Immunol. 208, 108253 (2019)
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Onuora, S. Novel cytokine, IL-41, linked with PsA. Nat Rev Rheumatol 15, 636 (2019). https://doi.org/10.1038/s41584-019-0314-7
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DOI: https://doi.org/10.1038/s41584-019-0314-7
