Sera from patients with either systemic lupus erythematosus (SLE) or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) induce distinct forms of neutrophil extracellular trap (NET) formation, according to a new study. In an ex vivo comparison, the NET formation differed in morphology, kinetics, triggers and pathways and resembled lytic and non-lytic mechanisms for AAV sera and SLE sera, respectively. Furthermore, the NETs produced had different compositions and immunogenic properties.
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van Dam, L. S. et al. Neutrophil extracellular trap formation is intrinsically distinct in ANCA-associated vasculitis and systemic lupus erythematosus. Arthritis Rheumatol. https://doi.org/10.1002/art.41047 (2019)
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McHugh, J. NET formation differs in SLE and vasculitis. Nat Rev Rheumatol 15, 512 (2019). https://doi.org/10.1038/s41584-019-0284-9
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DOI: https://doi.org/10.1038/s41584-019-0284-9
