The results of a risk estimation study suggest that the inheritance of osteoarthritis (OA) potentially occurs through the maternal line. The risk of OA was assessed in relation to family history of OA in participants from the Norwegian MUST and Nor-Twin OA studies (n = 630 and n = 7,175, respectively). Having a mother with OA consistently increased the risk of OA of any type in daughters (relative risk (RR)MUST 1.13, 95% CI 1.02–1.25; RRNor-Twin 1.44, 95% CI 1.05–1.97) and to a lesser degree in sons (RRMUST 1.16, 95% CI 0.95–1.43; RRNor-Twin 1.31, 95% CI 0.71–2.41). By contrast, having a father with OA did not increase the risk of OA of any type in either daughters or sons.
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Weldingh, E. et al. The maternal and paternal effects on clinical and surgical definitions of osteoarthritis. Arthritis Rheumatol. https://doi.org/10.1002/art.41023 (2019)
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Collison, J. Mother–daughter inheritance patterns in OA. Nat Rev Rheumatol 15, 450 (2019). https://doi.org/10.1038/s41584-019-0264-0
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DOI: https://doi.org/10.1038/s41584-019-0264-0
