Administration of intravenous abatacept <4 weeks before knee or hip arthroplasty was not associated with an increased risk of post-operative infection compared with halting therapy >4 weeks before surgery in a study of 1,780 patients with rheumatoid arthritis (RA). No significant differences were seen in the rates of hospitalized infection (total and non-urinary), 1-year prosthetic joint infection or 30-day readmission between patients who received abatacept <4 weeks or >4 weeks before surgery; however, glucocorticoid use during the 3 months prior to surgery was associated with an increased risk of infection.
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George, M. D. et al. Timing of abatacept before elective arthroplasty and risk of post-operative outcomes. Arthritis Care Res. https://doi.org/10.1002/acr.23843 (2019)
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Collison, J. No need for DMARD holiday before arthroplasty. Nat Rev Rheumatol 15, 188 (2019). https://doi.org/10.1038/s41584-019-0199-5
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DOI: https://doi.org/10.1038/s41584-019-0199-5