The risk of incident radiographic knee osteoarthritis (OA) over 5 years differed depending on an individual’s body composition (as determined by whole body dual energy x-ray) in a longitudinal cohort (n = 1,653). Sarcopenia was not associated with an increased risk of knee OA in men (relative risk (RR) 0.66, 95% CI 0.34–1.30) or in women (RR 0.96, 95% CI 0.62–1.49). By contrast, obesity was associated with an increased risk of knee OA in men (RR 1.73, 95% CI 1.08–2.78) and both obesity and sarcopenic obesity were associated with an increased risk of knee OA in women (obesity RR 2.29, 95% CI 1.64–3.20; sarcopenic obesity RR 1.91, 95% CI 1.17–3.11).
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Misra, D. et al. Risk of knee OA with obesity, sarcopenic obesity and sarcopenia. Arthritis Rheumatol. https://doi.org/10.1002/art.40692 (2018)
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Collison, J. Fat mass but not muscle mass linked to OA risk. Nat Rev Rheumatol 14, 560 (2018). https://doi.org/10.1038/s41584-018-0082-9
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DOI: https://doi.org/10.1038/s41584-018-0082-9
