Hot and bothered

The dorsomedial hypothalamus (DMH) drives the responses of the sympathetic nervous system to psychosocial stress; however, its inputs are not well understood. Kataoka et al. identified inputs to the rat DMH from the dorsal peduncular cortex and dorsal tenia tecta (DP/DTT). Social defeat stress induced cardiovascular and thermogenic sympathetic stress responses that were diminished by pharmacological or optogenetic inactivation of the DP/DTT, and mimicked through photostimulation of the DP/DTT. This DP/DTT–DMH circuit could be a potential target for treating stress-related disorders.


Original article

  1. Kataoka, N. et al. A central master driver of psychosocial stress responses in the rat. Science 357, 1105–1112 (2020)

Download references

Author information



Corresponding author

Correspondence to Natasha Bray.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bray, N. Hot and bothered. Nat Rev Neurosci 21, 245 (2020).

Download citation