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Has translation in the nucleus found its purpose?

Nature Reviews Molecular Cell Biology volume 25, pages 1–2 (2024)Cite this article

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Translation in the nucleus is a long-standing controversial issue with unclear physiological importance. Recent studies show that antigenic peptides for immune tolerance are derived from translation initiated at non-AUG codons of precursor mRNAs in the nucleus. It is therefore time to take a fresh look at nuclear translation and its interesting implications.

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Acknowledgements

The author is supported by Inserm and by the Czech Science Foundation (GACR 23-06884S).

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Authors and Affiliations

  1. Department of Medical Biosciences, Umeå University, Umeå, Sweden

    Robin Fåhraeus

  2. RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic

    Robin Fåhraeus

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  1. Robin Fåhraeus
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Correspondence to Robin Fåhraeus.

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Nature Reviews Molecular Cell Biology thanks the anonymous reviewers for their contribution to the peer review of this work.

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Fåhraeus, R. Has translation in the nucleus found its purpose?. Nat Rev Mol Cell Biol 25, 1–2 (2024). https://doi.org/10.1038/s41580-023-00651-6

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  • DOI: https://doi.org/10.1038/s41580-023-00651-6

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