The feasibility of long-term organ preservation ex vivo has been reported for the first time with proof of concept in human transplantation. Here, we discuss the possible applications of this novel technology in the clinical setting.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Giwa, S. et al. The promise of organ and tissue preservation to transform medicine. Nat. Biotechnol. 35, 530–542 (2017).
Nasralla, D. et al. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018).
Clavien, P.-A. et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nat. Biotechnol. 40, 1610–1616 (2022).
Eshmuminov, D. et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol. 38, 189–198 (2020).
European Association for the Study of the Liver. EASL Clinical Practice Guidelines: liver transplantation. J. Hepatol. 64, 433–485 (2016).
Tian, Y. et al. Liver graft regeneration in a rodent model of auxiliary partial liver xenotransplantation. Transplantation 94, 1136 (2012).
Todo, S. et al. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation. Hepatology 64, 632–643 (2016).
Taeger, C. D. et al. Extracorporeal perfusion for salvage of major amputates. Ann. Surg. 270, e5–e6 (2019).
ETH (Swiss Federal Institute of Technology in Zurich) and the University of Zurich (D.E. and P.-A.C.) have applied for a patent on this new perfusion technology (PCT/EP2019/051252).
Rights and permissions
About this article
Cite this article
Eshmuminov, D., Clavien, PA. Long-term dynamic ex vivo organ preservation. Nat Rev Gastroenterol Hepatol (2022). https://doi.org/10.1038/s41575-022-00727-2