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Location, location, location — spatial insight into hepatic macrophage populations

Nature Reviews Gastroenterology & Hepatology volume 19, pages 281–282 (2022)Cite this article

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The liver microenvironment has a dynamic complexity that has not yet been adequately described. A new omics study sheds light on the hepatic parenchymal and immune cell heterogeneity by focusing on the spatial distribution of myeloid cells and macrophages in homeostasis and nonalcoholic fatty liver disease.

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Fig. 1: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis are intrinsically linked with profound changes in liver histology and the hepatic immune environment.

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  1. Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany

    Adrien Guillot & Frank Tacke

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  1. Adrien Guillot
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  2. Frank Tacke
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Correspondence to Frank Tacke.

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The authors declare no competing interests.

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Guillot, A., Tacke, F. Location, location, location — spatial insight into hepatic macrophage populations. Nat Rev Gastroenterol Hepatol 19, 281–282 (2022). https://doi.org/10.1038/s41575-022-00600-2

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