GASTRIC CANCER

H. pylori elimination reduces gastric cancer risk

Although family history and Helicobacter pylori infection are the two main risk factors for gastric cancer, whether eradication of H. pylori benefits those with a family history of gastric cancer was unknown. In a single-centre study in South Korea, 1,676 first-degree relatives of patients with gastric cancer were randomly assigned to receive H. pylori eradication therapy or placebo. After a median follow-up of 9.2 years, gastric cancer developed in 10 individuals in the treatment group versus 23 in the placebo group (P = 0.03), suggesting that H. pylori eradication reduced the risk of gastric cancer in those with a familial risk.

References

Original article

  1. Choi, I. J. et al. Family history of gastric cancer and Helicobacter pylori treatment. N. Engl. J. Med. 382, 427–436 (2020)

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Iain Dickson.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dickson, I. H. pylori elimination reduces gastric cancer risk. Nat Rev Gastroenterol Hepatol 17, 194 (2020). https://doi.org/10.1038/s41575-020-0276-x

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing