Gut-brain axis

A Collection of Research, Reviews and News from across the Nature Research journals

Latest Reviews

  • Review |

    NAFLD is growing in prevalence worldwide, and has emerged as a leading cause of end-stage liver disease in many countries. In this Review, the authors describe the global epidemiology of NAFLD, discuss associated risk factors and outline challenges for screening and management.

    • Zobair Younossi
    • , Quentin M. Anstee
    • , Milena Marietti
    • , Timothy Hardy
    • , Linda Henry
    • , Mohammed Eslam
    • , Jacob George
    •  & Elisabetta Bugianesi
  • Review |

    Proton-pump inhibitors (PPIs) are widely used for gastric acid suppression in a number of gastric-acid-related diseases, including GERD. However, in recent years, increasing evidence of adverse events has been reported, raising concerns with clinicians and patients. This Review provides an update on the complications and risks of PPI use.

    • Peter Malfertheiner
    • , Arne Kandulski
    •  & Marino Venerito
  • Review |

    Patients who are obese and also consume excess alcohol are at increased risk of liver-related disease. In this Review, Parker and colleagues discuss how alcohol and obesity affect adipose tissue function, and describe the importance of the adipose-tissue–liver axis in liver disease pathogenesis and outcomes.

    • Richard Parker
    • , Seung-Jin Kim
    •  & Bin Gao
  • Review |

    IBD is associated with markedly reduced intestinal mucosal oxygen levels. In this Review, the authors discuss the role of mucosal hypoxia and hypoxia-induced signalling in IBD and identify potential targets for therapies, focusing on the cell-specific functions of hypoxia-inducible factors, prolyl hydroxylases and nuclear factor-κB.

    • Sophie Van Welden
    • , Andrew C. Selfridge
    •  & Pieter Hindryckx
  • Review |

    Direct-acting antiviral agents (DAAs) are highly effective treatments for HCV, but are not always accessible to people who inject drugs (PWID). Here, Grebely and colleagues outline the epidemiology of HCV in PWID, discuss current data on DAA outcomes in this population and highlight steps required to broaden access to HCV therapy with the eventual goal of HCV elimination.

    • Jason Grebely
    • , Behzad Hajarizadeh
    •  & Gregory J. Dore
  • Review |

    Endocrine (such as diabetes) and exocrine (such as pancreatitis) disorders of the pancreas have a substantial burden worldwide. This Review explores the potential of regenerative medicine and cell-based approaches to restore both endocrine and exocrine pancreatic function, describing insights into cell replacement, implantation and reprogramming.

    • Cara Ellis
    • , Adam Ramzy
    •  & Timothy J. Kieffer

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