The metabolic dysfunction that characterizes obesity and type 2 diabetes mellitus affects not only the heart and kidneys, but also the liver. Although lifestyle modification remains the cornerstone in the management of metabolic liver diseases, the field has progressed this year, with a new definition, validation of non-invasive biomarkers and numerous clinical trials.
Key advances
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Panels of non-invasive biomarkers have the potential to diagnose patients with NASH and those with NASH and fibrosis4.
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Panels of non-invasive biomarkers have predictive value for outcomes, especially those capturing the degree of fibrosis6.
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Drugs targeting new targets, such as thyroid hormone receptor-β and fibroblast growth factor 21, showed positive results in clinical trials8,9.
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There is a high degree of variability in the responses of the placebo groups in these trials8,9.
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References
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J.-F.D. declares the following competing interests: participation on advisory committees for Alentis, Astra-Zeneca, Bayer, Bristol-Myers Squibb, Enyo, Esai, Genfit, Intercept, Inventiva, Ipsen, Lilly, Madrigal, Merck, Novartis, Novo-Nordisk and Roche. Speaking and teaching engagements for Astra-Zeneca, Bristol-Myers Squibb, Intercept, Ipsen and Roche.
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Dufour, JF. A pivotal year for NAFLD and NASH therapeutics. Nat Rev Endocrinol 20, 75–76 (2024). https://doi.org/10.1038/s41574-023-00939-9
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DOI: https://doi.org/10.1038/s41574-023-00939-9
