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IMMUNE EVASION

Viral RNA in an m6A disguise

N6-methyladenosine (m6A) is a widespread modification on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways. A recent study demonstrates that viruses can use m6A to ensure their RNA avoids innate immune sensing.

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Fig. 1: Interplay between viral RNA synthesis, the cellular m6A modification system and RNA innate immune sensing.

References

  1. 1.

    Zhao, B. S., Roundtree, I. A. & He, C. Nat. Rev. Mol. Cell Biol. 18, 31–42 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Krug, R. M., Morgan, M. A. & Shatkin, A. J. J. Virol. 20, 45–53 (1976).

    CAS  Article  Google Scholar 

  3. 3.

    Williams, G. D., Gokhale, N. S. & Horner, S. M. Ann. Rev. Virol. 6, 235–253 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Gokhale, N. S. et al. Cell Host Microbe 20, 654–665 (2016).

    CAS  Article  Google Scholar 

  5. 5.

    Hao, H. et al. Nucleic Acids Res. 47, 362–374 (2019).

    CAS  Article  Google Scholar 

  6. 6.

    Durbin, A. F., Wang, C., Marcotrigiano, J. & Gehrke, L. mBio 7, e00833-16 (2016).

    Article  Google Scholar 

  7. 7.

    Daffis, S. et al. Nature 468, 452–456 (2010).

    CAS  Article  Google Scholar 

  8. 8.

    Zust, R. et al. Nat. Immunol. 12, 137–143 (2011).

    Article  Google Scholar 

  9. 9.

    Li et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0653-9 (2020).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

V.T. was supported by the Swiss National Science Foundation (SNF, grant no. 310030_173085).

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Correspondence to Volker Thiel.

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Thiel, V. Viral RNA in an m6A disguise. Nat Microbiol 5, 531–532 (2020). https://doi.org/10.1038/s41564-020-0689-x

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