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Viral RNA in an m6A disguise

Nature Microbiology volume 5, pages 531–532 (2020)Cite this article

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N6-methyladenosine (m6A) is a widespread modification on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways. A recent study demonstrates that viruses can use m6A to ensure their RNA avoids innate immune sensing.

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Fig. 1: Interplay between viral RNA synthesis, the cellular m6A modification system and RNA innate immune sensing.

References

  1. Zhao, B. S., Roundtree, I. A. & He, C. Nat. Rev. Mol. Cell Biol. 18, 31–42 (2017).

    Article  CAS  Google Scholar 

  2. Krug, R. M., Morgan, M. A. & Shatkin, A. J. J. Virol. 20, 45–53 (1976).

    Article  CAS  Google Scholar 

  3. Williams, G. D., Gokhale, N. S. & Horner, S. M. Ann. Rev. Virol. 6, 235–253 (2019).

    Article  CAS  Google Scholar 

  4. Gokhale, N. S. et al. Cell Host Microbe 20, 654–665 (2016).

    Article  CAS  Google Scholar 

  5. Hao, H. et al. Nucleic Acids Res. 47, 362–374 (2019).

    Article  CAS  Google Scholar 

  6. Durbin, A. F., Wang, C., Marcotrigiano, J. & Gehrke, L. mBio 7, e00833-16 (2016).

    Article  Google Scholar 

  7. Daffis, S. et al. Nature 468, 452–456 (2010).

    Article  CAS  Google Scholar 

  8. Zust, R. et al. Nat. Immunol. 12, 137–143 (2011).

    Article  Google Scholar 

  9. Li et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0653-9 (2020).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

V.T. was supported by the Swiss National Science Foundation (SNF, grant no. 310030_173085).

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Authors and Affiliations

  1. Institute of Virology and Immunology, Bern, Switzerland

    Volker Thiel

  2. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    Volker Thiel

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  1. Volker Thiel
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Correspondence to Volker Thiel.

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Thiel, V. Viral RNA in an m6A disguise. Nat Microbiol 5, 531–532 (2020). https://doi.org/10.1038/s41564-020-0689-x

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