Coordination of protein quality control processes across organelles is poorly understood. A study now shows that the cytosolic juxtanuclear quality control (JUNQ) and intranuclear quality control (INQ) compartments face each other on opposite sides of the nuclear envelope before their vacuolar degradation, promoting proteostasis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Alberti, S. & Hyman, A. A. Nat. Rev. Mol. Cell Bio.l 22, 196–213 (2021).
Sontag, E. M., Samant, R. S. & Frydman, J. Annu. Rev. Biochem. 86, 97–122 (2017).
Kumar, A., Mathew, V. & Stirling, P. C. J. Biol. Chem. 298, 102199 (2022).
Hipp, M. S., Kasturi, P. & Hartl, F. U. Nat. Rev. Mol. Cell Biol. 20, 421–435 (2019).
Sontag, E. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01128-6 (2023).
Kvam, E. & Goldfarb, D. S. Autophagy 3, 85–92 (2007).
den Brave, F. et al. Cell Rep. 31, 107680 (2020).
Kunadt, M. et al. Acta Neuropathol. 129, 695–713 (2015).
Li, Y. et al. J. Exp. Clin. Cancer Res. 38, 67 (2019).
Mediani, L. et al. EMBO J. 38, e101341 (2019).
Frottin, F. et al. Science 365, 342–347 (2019).
Pankiv, S. et al. J. Biol. Chem. 285, 5941–5953 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
S.A. is a scientific advisor to Dewpoint Therapeutics. S.C. declares no competing interests.
Rights and permissions
About this article
Cite this article
Alberti, S., Carra, S. A shared fate for nuclear and cytosolic inclusions. Nat Cell Biol 25, 629–630 (2023). https://doi.org/10.1038/s41556-023-01121-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01121-z