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Dynamics of mRNA entry into stress granules

Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

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Fig. 1: A model for mRNA entry into stress granules.


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Correspondence to Geraldine Seydoux.

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Lee, CY., Seydoux, G. Dynamics of mRNA entry into stress granules. Nat Cell Biol 21, 116–117 (2019).

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