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Cancer immunotherapies repurposed for use in autoimmunity

Nature Biomedical Engineering volume 3, pages 259–263 (2019)Cite this article

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Immunotherapies developed to treat cancer can be adapted to treat autoimmunity.

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Fig. 1: Immunotherapy using IL-2 and IL-2 derivatives can be used to promote the in vivo expansion of TCONV or TREG cells.
Fig. 2: Engineering the antigen specificity of T cells for enhancing their potency as a cellular therapy for cancer, autoimmunity or transplantation.

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Acknowledgements

The authors’ own work in this area is funded by the Canadian Institutes of Health Research (CIHR), TxCell SA, the Stem Cell Network, BioCanRx and the Helmsley Trust. D.A.B. holds a CIHR fellowship and M.K.L. receives a Scientist Salary Award from the BC Children’s Hospital Research Institute.

Author information

Authors and Affiliations

  1. Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada

    Dominic A. Boardman & Megan K. Levings

  2. BC Children’s Hospital Research Institute, Vancouver, British Columbia, Canada

    Dominic A. Boardman & Megan K. Levings

  3. School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada

    Megan K. Levings

Authors
  1. Dominic A. Boardman
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  2. Megan K. Levings
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Corresponding author

Correspondence to Megan K. Levings.

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Competing interests

M.K.L. has received research funding from TxCell, Pfizer and Bristol Myers Squibb, and has patents pending on alloantigen-specific chimaeric antigen receptors.

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Boardman, D.A., Levings, M.K. Cancer immunotherapies repurposed for use in autoimmunity. Nat Biomed Eng 3, 259–263 (2019). https://doi.org/10.1038/s41551-019-0359-6

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