Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Iridium-catalyzed enantioconvergent hydrogenation of trisubstituted olefins


Asymmetric hydrogenation of olefins constitutes a practical and efficient method to introduce chirality into prochiral substrates. However, the absolute majority of the developed methodologies is enantiodivergent and thus require isomerically pure olefins which is a considerable drawback since most olefination strategies produce (E/Z)-mixtures. Although some advances have been reported, a general enantioconvergent hydrogenation featuring a broad functional group tolerance remains elusive. Here, we report the development of a general iridium-catalyzed enantioconvergent hydrogenation of a broad range of functionalized trisubstituted olefins. The substitution pattern around the olefin is critical; whereas α-prochiral olefins can undergo an enantioconvergent hydrogenation, β-prochiral olefins react in an enantiodivergent manner. The presented methodology hydrogenates α-prochiral substrates with excellent control of enantioselection and high isolated yields. Most importantly, both isomerically pure alkenes as well as isomeric mixtures can be hydrogenated to yield the same major enantiomer in excellent enantiomeric excesses which is unusual in transition-metal catalyzed asymmetric hydrogenations.


Over the past decades, asymmetric catalysis has received increasing attention by exploring novel reactivity or improving selectivity issues1,2,3,4,5. Among the methods to introduce chirality, transition-metal catalyzed asymmetric hydrogenation using hydrogen gas has evolved as one of the most practical methods due to high reactivity, selectivity, atom-economy, and operational simplicity6,7,8,9,10,11. Considering the hydrogenation of carbon-carbon double bonds, nearly perfect chemo- and enantioselectivities have been obtained for a wide range of olefins by developing dedicated ligand libraries to target specific substitution patterns. These findings are important since enantiomers often exhibit different biological and pharmacological properties and as a consequence the pharma industry faces strict rules for the evaluation of potent drug candidates in enantiomerically pure form12,13. Despite the maturity of the field of asymmetric hydrogenation, the absolute majority of the hitherto developed systems are enantiodivergent (>99%, Fig. 1a)14,15,16,17,18. As a consequence, the geometrical purity around the olefin plays a critical role for both the sense and level of enantioinduction and thus the usefulness of the methodology. Therefore, difficult and time-consuming purification of olefinic substrates is often required prior to hydrogenation since classical olefination methodologies, in most cases, produce mixtures of (E/Z)-olefins. A classic example that demonstrates the necessity to use pure olefins is the synthesis of citronellol by Noyori in which opposite enantiomers were prepared by starting from either geraniol or nerol19. Most methodologies that are reported in more recent years still follow an enantiodivergent hydrogenation that was already observed over three decades ago.

Fig. 1: Reported asymmetric hydrogenation of olefins and limitations.
figure 1

a Enantiodivergent hydrogenation. b Enantioconvergent hydrogenation. BINAP, 2,2′-bis(diphenylphosphino)−1,1′-binaphthalene.

On the other hand, enantioconvergent hydrogenation of olefins is considered the pinnacle in state-of-the-art asymmetric hydrogenation and remains underdeveloped (<1% of all reported methodologies on the asymmetric hydrogenation of olefins, Fig. 1b)20. This is mainly attributed to the development of stereodefined catalytic pockets that is fine-tuned to maximize interactions in the hydrogenation of a single stereoisomer of the olefin. This often leads to lower synergy in the hydrogenation of the opposite stereoisomer and in addition, catalysts often show opposite enantioselection between (E)- and (Z)-olefins. This complicates the hydrogenation of isomeric mixtures since, in a useful enantioconvergent methodology, the enantioselectivity in the hydrogenation of both geometries of the olefin should yield the same enantiomer preferably in high selectivity. Although few enantioconvergent hydrogenations have been reported, these systems showed to be highly substrate-specific and require mostly multi-functionalized olefins and fine-tuned (transition-)metal catalysts20. Therefore, the development of a general enantioconvergent hydrogenation methodology that tolerates a broad range of olefinic starting materials remains an unsolved task.

In this report, we utilize a bidentate N,P-ligated iridium complex to hydrogenate various olefins in an enantioconvergent fashion (Fig. 2). To demonstrate the efficiency of the methodology, high levels of enantiopurity of the hydrogenated products were accessed by subjecting either pure isomeric olefins or a mixture of both.

Fig. 2: This work.
figure 2

FG functional group.

Results and discussion

Initial experiments and observations

The Andersson group has earlier developed a selectivity model to rationalize the stereochemical outcome of hydrogenations of trisubstituted olefins and iridium-N,P complexes21,22,23. Calculations have suggested that the coordination of an unfunctionalized olefin towards an [IrH2(N,P)(Solvent)2]+ complex takes place in the same equatorial plane as the chiral bidentate N,P-ligand and trans to phosphorus (Fig. 3a). The resultant quadrant model rationalizes whether the steric bulk of the ligand is above or below the N-Ir-P plane (Fig. 3b). To minimize steric interactions, the substrate then preferentially coordinates with the smallest olefin substituent, in this case the vinylic proton, to the hindered environment and thus coordinates by one of the enantiotopic faces in favor. This mode of coordination is supported by computational findings of other research groups using different iridium complexes24,25,26,27. Most important, experimental support for this hypothetical coordination was reported by an elegant low-temperature NMR study of Pfaltz in which a fundamental intermediate, an IrIII dihydride alkene complex akin to the above-described, was identified28. Intriguingly, although the model correctly predicts the stereochemical outcome for most olefins, it cannot be used for the hydrogenation of olefins having a conjugated carbonyl group29,30. Whereas the correct absolute configuration can be predicted for the formation of β-disubstituted carbonyl compounds, hydrogenation of α-disubstituted unsaturated carbonyl compounds yield the opposite enantiomer compared to the prediction (Fig. 3c).

Fig. 3: Origin and analysis of the stereoselectivity model.
figure 3

a Coordination of the ligand and the substrate to the iridium center. b Quadrant model based on the steric environment of the ligand around the coordinated olefin. c Predicted and experimentally observed stereochemical outcome for the hydrogenation of enones.

The failure of the model to predict the correct stereochemical outcome for the α-disubstituted enones indicates that this class of substrates might undergo hydrogenation via a different mechanism. Previous work already demonstrated that the hydrogenation of β-prochiral unsaturated carbonyl compounds follows the selectivity model and that it is also enantiodivergent which again is in accordance with the selectivity model (Fig. 4a)29,30. However, during the evaluation of the two isomeric forms of the α-disubstituted enone 1a it was found that both (E)-1a and (Z)-1a surprisingly gave rise to the (R)-enantiomer, and in high selectivity (99% and 95% ee respectively, Fig. 4b). That both the (E)- and (Z)-isomers of a given olefin produce the same enantiomer in high selectivity is an unusual phenomenon in asymmetric hydrogenations and we were therefore encouraged to investigate the generality of the observed enantioconvergent behavior.

Fig. 4: Enantiodivergent/enantioconvergent hydrogenation of trisubstituted enones.
figure 4

a β-Disubstituted enones. b α-Disubstituted enones. DCM dichloromethane, rt room temperature, COD 1,5-cyclooctadiene, BArF tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

Scope of enantioconvergent hydrogenation

First, we wanted to explore to what extent the convergent hydrogenation could be applied to a broader range of substrates. Various N-heterocyclic-phosphine ligated complexes were initially evaluated in the hydrogenation of (Z)-1b (see Supplementary Information for optimization details) and the aza-bicyclo thiazole backbone was found superior in terms of enantioselection. Modification of the phosphine substituents demonstrated that complex A hydrogenated both geometries of 1b in high enantioselectivity (96% ee from (E)-1b and 95% ee from (Z)-1b). Although catalyst A is also highly selective in the specific case of enones (99% ee from (E)-1a and 96% ee from (Z)-1a), a slightly improved selectivity was found when catalyst B was used. With the optimized reaction conditions in hand, (employing 1 mol% of the catalyst under 50 bar of hydrogen gas in DCM,) a large number of functional groups were found to be compatible and result in convergent reactions (Fig. 5). Chiral ketone 2a was obtained in excellent enantioselectivity (>99% ee), regardless of the geometry around the olefin of the starting α,β-unsaturated enone 1a. (Thio)ester and secondary amide derivatives 1b, 1c, and 1d were all well tolerated giving 96% ee, >99% ee, and >99% ee, respectively, also when isomeric mixtures of (E)- and (Z)-olefins were employed. Interestingly, evaluation of the complex ligated with the commercial PHOX ligand in the hydrogenation of 1a (E/Z, 87:13) provided 2b in only 22% ee (See Supplementary Information). To our delight, the enantioconvergent hydrogenation was not limited to carbonyl functional groups and phenyl sulfone 1e was hydrogenated in 92% ee. Although (Z)-ethyl phosphonate (Z)-1f underwent hydrogenation at a slower rate compared to (E)-1f, both isomers were hydrogenated in 97% ee. Despite vinyl nitro compound 1h and α-methylcinnamic acid 1g were hydrogenated in lower reactivity and/or selectivity, both substrates were found to follow an enantioconvergent mechanism. Additionally, γ-diesters 3a and 3b were also tolerated resulting in 96% ee and 99% ee of the corresponding hydrogenated products 4a and 4b, respectively, also when mixtures of (E/Z) were subjected to the reaction. The γ-ketoester 3c resulted in a larger rate difference between isomeric starting materials, however, a 1:4 (E/Z) mixture was hydrogenated in excellent results of 97% ee and 91% isolated yield.

Fig. 5: Enantioconvergent hydrogenation of trisubstituted olefins.
figure 5

Reaction conditions: 0.1 mmol substrate, 1.0 mol% catalyst, 2 mL DCM, 50 bar H2, 16 h, rt, unless otherwise stated. Isomerically pure starting materials were evaluated on 0.05 mmol scale in 1 mL DCM and conversion was determined by 1H NMR spectroscopy. Enantiomeric excess was determined by SFC or GC analysis, using chiral stationary phases. [a] Catalyst B was used. [b] 100 bar H2. [c] 2.0 mol% catalyst. FG functional group, DCM dichloromethane, rt room temperature, COD 1,5-cyclooctadiene, BArF tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, conv. conversion.

Next, a range of substituted α,β-unsaturated ketones were evaluated using catalyst B (Fig. 6). The reaction showed to be insensitive to the electronic properties of the phenyl ring as both strong electron-donating and electron-withdrawing substituents in all positions of the aromatic ring were hydrogenated in excellent results (2aa2af, 98->99% ee, also when starting from 1:1 mixtures of (E/Z)-isomers). In addition, para-bromo and para-ethyl ester substrates were both hydrogenated in enantioselectivity of 99% ee (2ag and 2ah). Changing the methyl group on the α-position to ethyl and n-butyl both afforded the chiral ketones in >99% ee (2ai and 2aj) whereas the α-phenyl enone 1ak was hydrogenated with a slight decrease in enantioselectivity (93% ee). Cyclohexanone and cycloheptanone-derived enones 1al and 1am were both hydrogenated in 99% ee as mixtures of starting geometries. Different substituents on the ketone side-chain were also evaluated and hydrogenation of ethyl, i-propyl, i-butyl, and phenyl substituted ketone all yielded the desired products in 98->99% ee (2an2aq). Finally, both naphthyl, as well as various heteroaromatic substrates, were all hydrogenated in excellent enantioselectivities and isolated yields (1ar1ax, 97->99% ee, >90% yield), also when 1:1 isomeric mixtures were employed (no conversion was obtained when the hydrogenations of R1 = 3-pyridyl, 4-pyridyl or 2-thiazolyl with R2 = R3 = Me were attempted. The heteroaromatic moiety most likely forms a ligand on the iridium complex, alternatively, it is too basic and deprotonates the iridium dihydrogen complex).

Fig. 6: Enantioconvergent hydrogenation of trisubstituted unsaturated enones.
figure 6

Reaction conditions: 0.1 mmol substrate, 1.0 mol% catalyst, 2 mL DCM, 50 bar H2, 16 h, rt. Isomerically pure starting materials were evaluated on 0.05 mmol scale in 1 mL DCM and conversion was determined by 1H NMR spectroscopy. Enantiomeric excess was determined by SFC or GC analysis, using chiral stationary phases. DCM dichloromethane, rt room temperature, COD 1,5-cyclooctadiene, BArF tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, conv. conversion.

Scale-up enantioconvergent hydrogenation, sequential olefination/hydrogenation, and mechanistic experiment

Then, the developed protocol was evaluated on a gram-scale and 1a was smoothly hydrogenated as a mixture of geometries to provide 2a in optically pure form (99% ee) and 98% yield (Fig. 7a). In addition, the usefulness of this methodology was demonstrated in the hydrogenation of 1f which geometrical isomers cannot be separated by ordinary column chromatography (silica). The synthesis of 1f by a Peterson olefination provided a 32:68 (E/Z) mixture which was isolated by a quick flash column chromatography and subsequently hydrogenated to give 2f in 97% ee (Fig. 7b).

Fig. 7: Practical applications and deuterium gas study.
figure 7

a Gram-scale enantioconvergent hydrogenation. b Olefination/hydrogenation sequence. c D2-gas hydrogenation. DCM dichloromethane, rt room temperature, LDA lithium diisopropylamide, TMSCl trimethylsilyl chloride, conv. conversion.

As last, our group recently reviewed20 the proposed mechanisms for enantioconvergent hydrogenations and concluded that they can either be due to; (1) a dynamic isomerization between the (E)- and (Z)-geometry of the starting olefin, accompanied with a large difference in hydrogenation rate for the two isomeric forms. Or, (2) by a chelation-controlled hydrogenation for substrates possessing a coordinating group on the prochiral carbon of the olefin. In order to exclude one of these two mechanistic possibilities, deuterium-labeling experiments were performed. Individual hydrogenation of both (E)-1aa and (Z)-1aa under D2 atmosphere resulted in the formation of two different diastereomeric products (Fig. 7c). This indicates that the enantioconvergent hydrogenation is not a result of isomerization between starting geometries prior to hydrogenation.

In summary, we have developed a general and highly efficient strategy for the enantioconvergent hydrogenation of trisubstituted olefins using a bidentate N,P-ligated iridium complex. The reaction tolerates a broad substrate scope of α-prochiral functionalized olefins in terms of chelating functional group as well as a wide range of (heteroaromatic) substitution patterns. The olefins can be hydrogenated either in isomerically pure forms or as isomeric mixtures yielding the same absolute configuration in excellent enantiomeric excess and isolated yield. We anticipate that our findings will be applicable to a large number of asymmetric hydrogenations of mixtures of (E)- and (Z)-olefins.


General procedure for the enantioconvergent hydrogenation

An oven-dried vial was charged with olefin (0.1 mmol, 1.0 equiv.) and Ir-N,P-catalyst (1.0 mol%). DCM (2 mL) and a magnetic stirring bar were added and the vial was placed in a high-pressure hydrogenation apparatus. The reactor was purged three times with Ar, purged three times with H2 and then pressurized with H2 (50–100 bar). The reaction was stirred at room temperature for 16 h before the H2 pressure was released and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (pentane/Et2O, 50/50) on silica gel to give the alkane. The ee value was determined by GC analysis or SFC analysis on the chiral stationary phase. The corresponding racemic product was used for comparison and it was prepared on a 0.05-mmol scale using Pd/C (or racemic Ir-catalyst) as the catalyst, following the same hydrogenation procedure. The absolute configuration was determined by comparing the sign of optical rotation with reported values.

Data availability

Experimental procedures, catalyst screening, characterization data of new compounds, separation of chiral products, and NMR spectra of new compounds are available in the Supplementary Information. All data is available from the authors upon request.


  1. Shaw, S. & White, J. D. Asymmetric catalysis using chiral salen–metal complexes: recent advances. Chem. Rev. 119, 9381–9426 (2019).

    CAS  Article  Google Scholar 

  2. Chen, Y., Yekta, S. & Yudin, A. K. Modified BINOL ligands in asymmetric catalysis. Chem. Rev. 103, 3155–3212 (2003).

    CAS  Article  Google Scholar 

  3. Hargaden, G. C. & Guiry, P. J. Recent applications of oxazoline-containing ligands in asymmetric catalysis. Chem. Rev. 109, 2505–2550 (2009).

    CAS  Article  Google Scholar 

  4. Genet, J.-P., Ayad, T. & Ratovelomanana-Vidal, V. Electron-deficient diphosphines: the impact of DIFLUORPHOS in asymmetric catalysis. Chem. Rev. 114, 2824–2880 (2014).

    CAS  Article  Google Scholar 

  5. McManus, H. A. & Guiry, P. J. Recent developments in the application of oxazoline-containing ligands in asymmetric catalysis. Chem. Rev. 104, 4151–4202 (2004).

    CAS  Article  Google Scholar 

  6. Roseblade, S. J. & Pfaltz, A. Iridium-catalyzed asymmetric hydrogenation of olefins. Acc. Chem. Res. 40, 1402–1411 (2007).

    CAS  Article  Google Scholar 

  7. Chirik, P. J. Iron- and cobalt-catalyzed alkene hydrogenation: catalysis with both redox-active and strong field ligands. Acc. Chem. Res. 48, 1687–1695 (2015).

    CAS  Article  Google Scholar 

  8. Verendel, J. J., Pàmies, O., Diéguez, M. & Andersson, P. G. Asymmetric hydrogenation of olefins using chiral crabtree-type catalysts: scope and limitations. Chem. Rev 114, 2130–2169 (2014).

    CAS  Article  Google Scholar 

  9. Minnaard, A. J., Feringa, B. L., Lefort, L. & de Vries, J. G. Asymmetric hydrogenation using monodentate phosphoramidite ligands. Acc. Chem. Res. 40, 1267–1277 (2007).

    CAS  Article  Google Scholar 

  10. Zhang, W., Chi, Y. & Zhang, X. Developing chiral ligands for asymmetric hydrogenation. Acc. Chem. Res. 40, 1278–1290 (2007).

    CAS  Article  Google Scholar 

  11. Etayo, P. & Vidal-Ferran, A. Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs. Chem. Soc. Rev. 42, 728–754 (2013).

    CAS  Article  Google Scholar 

  12. Jozwiak, K., Lough, W. J. & Wainer, I. W. Drug Stereochemistry: Analytical Methods and Pharmacology. 3rd ed. (CRC Press, 2012).

  13. Brooks, W. H., Guida, C. & Daniel, K. G. The significance of chirality in drug design and development. Curr. Top. Med. Chem. 11, 760–770 (2011).

    CAS  Article  Google Scholar 

  14. Powell, M. T., Hou, D.-R., Perry, M. C., Cui, X. & Burgess, K. Chiral imidazolylidine ligands for asymmetric hydrogenation of aryl alkenes. J. Am. Chem. Soc. 123, 8878–8879 (2001).

    CAS  Article  Google Scholar 

  15. Wang, A., Wüstenberg, B. & Pfaltz, A. Enantio- and diastereoselective hydrogenation of farnesol and o-protected derivatives: stereocontrol by changing the C=C bond configuration. Angew. Chem. Int. Ed. 47, 2298–2300 (2008).

    CAS  Article  Google Scholar 

  16. Peters, B. K. et al. An enantioselective approach to the preparation of chiral sulfones by Ir-catalyzed asymmetric hydrogenation. J. Am. Chem. Soc. 136, 16557–16562 (2014).

    CAS  Article  Google Scholar 

  17. Liu, G., Han, Z., Dong, X.-Q. & Zhang, X. Rh-catalyzed asymmetric hydrogenation of β-substituted-β-thio-α,β-unsaturated esters: expeditious access to chiral organic sulfides. Org. Lett. 20, 5636–5636 (2018).

    CAS  Article  Google Scholar 

  18. Yan, Q. et al. Highly efficient enantioselective synthesis of chiral sulfones by Rh-catalyzed asymmetric hydrogenation. J. Am. Chem. Soc. 141, 1749–1756 (2019).

    CAS  Article  Google Scholar 

  19. Takaya, H. et al. Enantioselective hydrogenation of allylic and homoallylic alcohols. J. Am. Chem. Soc. 109, 1596–1597 (1987).

    CAS  Article  Google Scholar 

  20. Massaro, L., Zheng, J., Margarita, C. & Andersson, P. G. Enantioconvergent and enantiodivergent catalytic hydrogenation of isomeric olefins. Chem. Soc. Rev. 49, 2504–2522 (2020).

    CAS  Article  Google Scholar 

  21. Brandt, P., Hedberg, C. & Andersson, P. G. New mechanistic insights into the iridium-phosphanooxazoline-catalyzed hydrogenation of unfunctionalized olefins: a DFT and kinetic study. Chem. Eur. J. 9, 339–347 (2003).

    CAS  Article  Google Scholar 

  22. Church, T. L., Rasmussen, T. & Andersson, P. G. Enantioselectivity in the iridium-catalyzed hydrogenation of unfunctionalized olefins. Organometallics 29, 6769–6781 (2010).

    CAS  Article  Google Scholar 

  23. Hedberg, C., Källström, K., Brandt, P., Hansen, L. K. & Andersson, P. G. Asymmetric hydrogenation of trisubstituted olefins with iridium-phosphine thiazole complexes: a further investigation of the ligand structure. J. Am. Chem. Soc. 128, 2995–3001 (2006).

    CAS  Article  Google Scholar 

  24. Perry, M. C. et al. Optically active iridium imidazol-2-ylidene-oxazoline complexes: preparation and use in asymmetric hydrogenation of arylalkenes. J. Am. Chem. Soc. 125, 113–123 (2003).

    CAS  Article  Google Scholar 

  25. Fan, Y., Cui, X., Burgess, K. & Hall, M. B. Electronic effects steer the mechanism of asymmetric hydrogenations of unfunctionalized aryl-substituted alkenes. J. Am. Chem. Soc. 126, 16688–16689 (2004).

    CAS  Article  Google Scholar 

  26. Rageot, D., Woodmansee, D. H., Pugin, B. & Pfaltz, A. Proline-based P,O ligand/iridium complexes as highly selective catalysts: asymmetric hydrogenation of trisubstituted alkenes. Angew. Chem. Int. Ed. 50, 9598–9601 (2011).

    CAS  Article  Google Scholar 

  27. Mazuela, J., Norrby, P.-O., Andersson, P. G., Pàmies, O. & Diéguez, M. Pyranoside phosphite-oxazoline ligands for the highly versatile and enantioselective ir-catalyzed hydrogenation of minimally functionalized olefins. a combined theoretical and experimental study. J. Am. Chem. Soc. 133, 13634–13645 (2011).

    CAS  Article  Google Scholar 

  28. Gruber, S. & Pfaltz, A. Asymmetric hydrogenation with iridium C,N and N,P ligand complexes: characterization of dihydride intermediates with a coordinated alkene. Angew. Chem. Int. Ed. 53, 1896–1900 (2014).

    CAS  Article  Google Scholar 

  29. Li, J.-Q., Quan, X. & Andersson, P. G. Highly enantioselective iridium-catalyzed hydrogenation of α,β-unsaturated esters. Chem. Eur. J 18, 10609–10616 (2012).

    CAS  Article  Google Scholar 

  30. Peters, B. B. C., Jongcharoenkamol, J., Krajangsri, S. & Andersson, P. G. Highly enantioselective iridium-catalyzed hydrogenation of conjugated trisubstituted enones. Org. Lett. 23, 242–246 (2021).

    CAS  Article  Google Scholar 

Download references


The authors thank the Swedish Research Council (VR), the Knut and Alice Wallenberg foundation (KAW 2016:0072 & KAW 2018:0066) and Stiftelsen Olle Engkvist Byggmästare for their financial support. T.S. acknowledges the National Research Foundation (NRF) South Africa for the Post-PhD Thuthuka grant for financial support.


Open access funding provided by Stockholm University.

Author information

Authors and Affiliations



P.G.A. supervised the project. B.B.C.P. started the project and optimized the reaction. The substrates were synthesized by B.B.C.P., J.Z., and N.B. and were evaluated by B.B.C.P. and J.Z. The reactivity of the catalysts was studied by T.S. The manuscript was prepared by B.B.C.P., P.G.A., and J.Z. and the SI was prepared by B.B.C.P. and J.Z.

Corresponding author

Correspondence to Pher G. Andersson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Peer review

Peer review information

Nature Communications thanks Ilya Grindev and the anonymous reviewer(s) for their contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Peters, B.B.C., Zheng, J., Birke, N. et al. Iridium-catalyzed enantioconvergent hydrogenation of trisubstituted olefins. Nat Commun 13, 361 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing