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Intermediate-term results of TachoSil grafting to correct residual curvature during inflatable penile prosthesis implantation in patients with Peyronie’s disease

International Journal of Impotence Research volume 35, pages 647–650 (2023)Cite this article

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Abstract

Grafting techniques may be mandatory to improve residual penile curvature during inflatable penile prosthesis (IPP) implantation in Peyronie’s disease patients. We aimed to report the intermediate-term outcomes of grafting with TachoSil (Corza Health, San Diego, USA) in patients with severe erectile dysfunction and concomitant complex Peyronie’s disease through a prospective cohort study. We included 25 patients that underwent the PICS (penile implant in combination with Sealing) technique from 2017 to 2020 and were evaluated 24 months after surgery. Their mean age was 61.8 ± 8.7 years. Total straightness of the penis was achieved in 21 cases, while 4 (16%) patients presented a residual penile curvature of less than 15°. The mean penile length increased significantly (15 ± 1.2 to 16.4 ± 1.6 cm, p < 0.001). No intraoperative complications occurred, while, postoperatively, two patients developed fever and three scrotal hematoma, which resolved spontaneously. At three and six weeks, as well as at 24 months after surgery, no further complications occurred, and no cases of penile glans hyposensitivity were observed. At the 24-month follow-up evaluation, the 5-item score of the International Index of Erectile Function was 23.7 ± 1.4 (range: 20.5-25) and all patients responded positively to questions 2 and 3 of the sexual encounter profile questionnaire (p < 0.001 for all outcomes compared to baseline). Accordingly, the Erectile Dysfunction Inventory of Treatment Satisfaction score improved from 45.8 ± 6 at baseline to 25.6 ± 4.6 at 24 months, p < 0.001. Grafting with TachoSil to improve residual penile curvature during IPP is a safe and effective procedure. Nevertheless, careful patient selection and counseling, surgeon’s experience with the technique, and strict postoperative penile rehabilitation are the main factors for treatment success and high satisfaction rates.

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Data availability

The data that support the findings of this study are available from the corresponding author, GH, upon reasonable request.

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Authors and Affiliations

  1. Department of Urology, Martha-Maria Hospital Nuremberg, Nuremberg, Germany

    Nikolaos Pyrgidis, Ioannis Sokolakis & Georgios Hatzichristodoulou

  2. 2nd Department of Urology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Ioannis Sokolakis

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  1. Nikolaos Pyrgidis
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  3. Georgios Hatzichristodoulou
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All authors participated in the drafting, writing, and editing of the manuscript. All gave final approval and agreed to be accountable for all aspects of work ensuring integrity and accuracy.

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Correspondence to Georgios Hatzichristodoulou.

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Pyrgidis, N., Sokolakis, I. & Hatzichristodoulou, G. Intermediate-term results of TachoSil grafting to correct residual curvature during inflatable penile prosthesis implantation in patients with Peyronie’s disease. Int J Impot Res 35, 647–650 (2023). https://doi.org/10.1038/s41443-023-00708-2

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