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Association of blood pressure and hyperuricemia with proteinuria and reduced renal function in the general population

Hypertension Research volume 46, pages 1662–1672 (2023)Cite this article

A Comment to this article was published on 20 April 2023

Abstract

This study aimed to investigate the effect of hyperuricemia (HU) on the association of systolic blood pressure (SBP) with the prevalence of proteinuria and low estimated glomerular filtration rate (eGFR) in the general population. This cross-sectional study enrolled 24,728 Japanese individuals (11,137 men and 13,591 women) who underwent health checkups in 2010. The prevalence of proteinuria and low eGFR (< 60 mL/min/1.73 m2) among participants classified according to serum uric acid levels and SBP was compared. HU was defined as serum uric acid levels higher than the 75th percentile in male and female participants (> 7.2 and > 5.4 mg/dL, respectively). The odds ratio (OR) for proteinuria increased with elevated SBP. This trend was significantly evident in participants with HU. Moreover, there was an interactive effect of SBP and HU on the prevalence of proteinuria in the male (Pfor interaction = 0.04) and female (Pfor interaction = 0.04) participants. Next, we evaluated the OR for low eGFR (< 60 mL/min/1.73 m2) with and without proteinuria based on the presence of HU. The multivariate analysis revealed that the OR for low eGFR with proteinuria increased with elevated SBP, but that for low eGFR without proteinuria decreased. These trends of OR tended to be prevalent among those with HU. The association between SBP and the prevalence of proteinuria was more pronounced in participants with HU. However, the association between SBP and decreased renal function with and without proteinuria might be different regardless of HU.

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Acknowledgements

The authors are grateful to Dr. Kinjyo K, the chairman of the Okinawa General Health Association, Haebaru, Japan, for providing the data for analysis.

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Authors and Affiliations

  1. Yuuaikai Tomishiro Central Hospital, Tomigusuku, Japan

    Masako Kochi

  2. Dialysis Unit, University of the Ryukyus Hospital, Nishihara, Japan

    Kentaro Kohagura & Ryo Zamami

  3. Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan

    Nanako Oshiro, Ryo Zamami & Yusuke Ohya

  4. Okinawa Rehabilitation Center Hospital, Okinawa, Japan

    Kazufumi Nagahama

  5. Department of Public Health and Hygiene, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan

    Koshi Nakamura

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  1. Masako Kochi
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Correspondence to Kentaro Kohagura.

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Dr. Kohagura received personal fees for lecture from Teijin Pharma, Fuji Pharma, Sanwa Kagaku, Pfizer, and Mochida Pharma as well as obtained research funding from Teijin Pharma, outside the submitted work.

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Kochi, M., Kohagura, K., Oshiro, N. et al. Association of blood pressure and hyperuricemia with proteinuria and reduced renal function in the general population. Hypertens Res 46, 1662–1672 (2023). https://doi.org/10.1038/s41440-023-01250-w

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