Expression of Concern to: Cancer Gene Therapy https://doi.org/10.1038/sj.cgt.7700305, published online 22 June 2001
The Editor-in-Chief is issuing an editorial Expression of Concern to alert readers that concerns have been raised regarding the data in this article, specifically:
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the blot in Figure 1b is duplicated from Figure 5 in another paper [1], but used with a different label
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the blot in Figure 5 for SKOV3-NRTIS has duplicated 0 & 24 lanes with 48 & 72 lanes for p32 and p17, with a cut between them
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the blot in Figure 6d for IGROV1-NRTIS for the lower panel has duplicated the mock infected lane and the Ad LM-tk + lane
The concerns have been investigated by Barts Cancer Institute (BCI) and the results of this investigation were reviewed by Imperial College London. Both BCI and Imperial College London have stated that since the research took place over 20 years ago the original data are no longer available and therefore a correction is not possible. Readers are advised to interpret the results with caution. I. A. McNeish, T. Tenev, M. Marani, G. Vassuax and N. Lemoine agree with this statement. S. Bell is deceased.
Reference
Tenev T, Marani M, McNeish I, Lemoine NR. Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors. Cell Death Differ. 2001;8:256–64. https://doi.org/10.1038/sj.cdd.4400808
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McNeish, I.A., Tenev, T., Bell, S. et al. Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells. Cancer Gene Ther (2024). https://doi.org/10.1038/s41417-024-00777-5
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DOI: https://doi.org/10.1038/s41417-024-00777-5
