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Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia

Cancer Gene Therapy volume 26, pages 17–25 (2019)Cite this article

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Abstract

iASPP is a negative regulator of the apoptotic function of p53, and it can enhance the ability of hematopoietic stem cells to self-renew and resist chemo- and radiation therapy. Recent study showed that iASPP could impact the proliferation and apoptosis of leukemia cells by interacting with FHL2. However, whether they have prognostic significance in acute myeloid leukemia (AML) is unknown. Eighty-four AML patients with FHL2 and iASPP expression data from The Cancer Genome Atlas database were enrolled in the study. Patients with high expressions of FHL2 and iASPP had significantly shorter event-free survival (EFS) and overall survival (OS) than patients with low expressions (P = 0.005, P = 0.003, respectively). Univariate analysis indicated that high expressions of FHL2 or iASPP were unfavorable for EFS and OS (all P < 0.05), while multivariate analysis confirmed that high FHL2 expression was an independent risk factor for EFS and OS (all P < 0.05). In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. Our results suggested that high expressions of FHL2 and iASPP were poor prognostic factors for AML, but the prognostic effect might be overcome by allo-HSCT.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81500118, 61501519), the China Postdoctoral Science Foundation funded project (Project No.2016M600443), Jiangsu Province Postdoctoral Science Foundation funded project (Project No.1701184B), PLAGH project of Medical Big Data (Project No.2016MBD-025) and Beijing Natural Science Foundation (7164310).

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Author notes

  1. These authors contributed equally: Yang Chen, Depei Wu, Jinlong Shi, Lin Fu

Authors and Affiliations

  1. Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China

    Zhiheng Cheng & Jinlong Shi

  2. Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China

    Zhiheng Cheng, Xiaoyan Ke & Lin Fu

  3. Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, 515041, China

    Zhiheng Cheng & Yifeng Dai

  4. Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands

    Yifeng Dai

  5. Department of Medicine, William Beaumont Hospital, Royal Oak, MI, 48073, USA

    Yifan Pang

  6. Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, 310058, China

    Yang Jiao

  7. Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China

    Hongmian Zhao, Tong Qin, Ning Hu & Lin Fu

  8. Department of Stomatology, Peking University, Third Hospital, Beijing, 100191, China

    Zhihui Zhang

  9. Department of Respiratory, Huaihe Hospital of Henan University, Kaifeng, 475000, China

    Yijie Zhang

  10. MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, School of Medicine, Tsinghua University, Beijing, 100084, China

    Yang Chen

  11. Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

    Depei Wu & Lin Fu

  12. Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing, 100853, China

    Jinlong Shi

  13. Department of Medical Big Data, Chinese PLA General Hospital, Beijing, 100853, China

    Jinlong Shi

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  1. Zhiheng Cheng
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Correspondence to Depei Wu, Jinlong Shi or Lin Fu.

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Cheng, Z., Dai, Y., Pang, Y. et al. Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia. Cancer Gene Ther 26, 17–25 (2019). https://doi.org/10.1038/s41417-018-0027-0

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