Correction to: Laboratory Investigation

https://doi.org/10.1038/s41374-021-00591-9

The original version of this article unfortunately contained a mistake. Due to a typeset error the Summary was omitted. We apologize for the error. The original article has been corrected.

Summary

The expression of TRIM27 in MRL/lpr mice and human renal glomerular endothelial cells cultured in vitro is significantly enhanced. Down-regulating the expression of TRIM27 inhibits the loss of glycocalyx and damage to endothelial cells through the FoxO1 pathway. In addition, inhibition of the protein kinase B (Akt) pathway can reduce the damage by mediating the expression of TRIM27.