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Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

Journal of Perinatology volume 41, pages 1313–1321 (2021)Cite this article

Subjects

Abstract

Objective

To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks’ gestation at 18–24 months of corrected age.

Study design

Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes.

Results

The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00–2.54).

Conclusions

Risk of NDI was similar between LGA and AGA infants.

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Data availability

The data sets generated and analyzed during this study are with PSS, Director CNN, but current data transfer approval agreements do not allow for data to be made available to others.

References

  1. Cartwright R, Anderson NH, Sadler LC, Harding JE, McCowan LME, McKinlay CJD. Neonatal morbidity and small and large size for gestation: a comparison of birthweight centiles. J Perinatol. 2020;40:10.

    Article  Google Scholar 

  2. Boghossian NS, Geraci M, Edwards EM, Horbar JD. Morbidity and mortality in small for gestational age infants at 22 to 29 weeks’ gestation. Pediatrics. 2018;141:e20172533.

    Article  PubMed  Google Scholar 

  3. Nobile S, Marchionni P, Carnielli VP. Neonatal outcome of small for gestational age preterm infants. Eur J Pediatr. 2017;176:6.

  4. De Jesus LC, Pappas A, Shankaran S, Li L, Das A, Bell EF, et al. Outcomes of small for gestational age infants born at <27 weeks’ gestation. J Pediatr. 2013;163:55–60 e51-53.

    Article  Google Scholar 

  5. ElSayed E, Daspal S, Yee W, Pelausa E, Canning R, Shah PS, et al. Outcomes of singleton small for gestational age preterm infants exposed to maternal hypertension: a retrospective cohort study. Pediatr Res. 2019;86:269–75.

    Article  PubMed  Google Scholar 

  6. Sacchi C, Marino C, Nosarti C, Vieno A, Visentin S, Simonelli A. Association of intrauterine growth restriction and small for gestational age status with childhood cognitive outcomes: a systematic review and meta-analysis. JAMA Pediatr. 2020;174:772–81.

    Article  PubMed  Google Scholar 

  7. Arcangeli T, Thilaganathan B, Hooper R, Khan KS, Bhide A. A neurodevelopmental delay in small babies at term: a systematic review. Ultrasound Obstet Gynecol. 2012;40:267–75.

    Article  CAS  PubMed  Google Scholar 

  8. Mericq V, Martinez-Aguayo A, Uauy R, Iniguez G, Van der Steen M, Hokken-Koelega A. Long-term metabolic risk among children born premature or small for gestational age. Nat Rev Endocrinol. 2017;13:50–62.

    Article  CAS  PubMed  Google Scholar 

  9. Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the international societies of pediatric endocrinology and the growth hormone research society. J Clin Endocr Metab. 2007;92:804–10.

    Article  CAS  PubMed  Google Scholar 

  10. Chiavaroli VDJ, Hofman PL, Cutfield WS. Born large for gestational age: bigger is not always better. J Pediatr. 2016;170:307–11.

    Article  PubMed  Google Scholar 

  11. Kramer MS, Morin I, Yang H, Platt RW, Usher R, McNamara H, et al. Why are babies getting bigger? Temporal trends in fetal growth and its determinants. J Pediatr. 2002;141:538–42.

    Article  PubMed  Google Scholar 

  12. Dabelea D, Crume T. Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes. 2011;60:1849–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Catalano PM. Obesity and pregnancy-the propagation of a viscous cycle? J Clin Endocrinol Metab. 2003;88:3505–6.

    Article  PubMed  Google Scholar 

  14. Goldstein RF, Abell SK, Ranasinha S, Misso ML, Boyle JA, Harrison CL, et al. Gestational weight gain across continents and ethnicity: systematic review and meta-analysis of maternal and infant outcomes in more than one million women. BMC Med. 2018;16:153.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Chauhan SP, Rice MM, Grobman WA, Bailit J, Reddy UM, Wapner RJ, et al. Neonatal morbidity of small- and large-for-gestational-age neonates born at term in uncomplicated pregnancies. Obstet Gynecol. 2017;130:511–9.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ibiebele I, Bowen JR, Nippita TA, Morris JM, Ford JB. Childhood health and education outcomes following early term induction for large-for-gestational age: A population-based record linkage study. Acta Obstet Gynecol Scand. 2019;98:423–32.

    Article  PubMed  Google Scholar 

  17. Lei X, Zhao D, Huang L, Luo Z, Zhang J, Yu X, et al. Childhood health outcomes in term, large-for-gestational-age babies with different postnatal growth patterns. Am J Epidemiol. 2018;187:507–14.

    Article  PubMed  Google Scholar 

  18. Moore GS, Kneitel AW, Walker CK, Gilbert WM, Xing G. Autism risk in small- and large-for-gestational-age infants. Am J Obstet Gynecol. 2012;206:314 e311–319.

    Article  Google Scholar 

  19. Khambalia AZ, Algert CS, Bowen JR, Collie R, Roberts CL. Long-term outcomes for large for gestational age infants born at term. Paediatrics Child Health Div. 2017;53:876–81.

    Article  Google Scholar 

  20. Baer RJ, Rogers EE, Partridge JC, Anderson JG, Morris M, Kuppermann M, et al. Population-based risks of mortality and preterm morbidity by gestational age and birth weight. J Perinatol. 2016;36:1008–13.

    Article  CAS  PubMed  Google Scholar 

  21. Boghossian NS, Geraci M, Edwards EM, Horbar JD. In-hospital outcomes in large for gestational age infants at 22-29 weeks of gestation. J Pediatr. 2018;198:174–80 e113.

    Article  PubMed  Google Scholar 

  22. Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R, et al. Variations in practice and outcomes in the Canadian NICU network: 1996–7. Pediatrics. 2000;106:1070–9.

    Article  CAS  PubMed  Google Scholar 

  23. Shah PS, Seidlitz W, Chan P, Yeh S, Musrap N, Lee SK, et al. Internal audit of the Canadian Neonatal Network Data Collection System. Am J Perinatol. 2017;34:1241–9.

    Article  PubMed  Google Scholar 

  24. Canadian Neonatal Follow-Up Network. 18-month corrected age assessment manual. Neonatal folow-up network. Toronto, Canada: Canadian Neonatal Follow-Up Network; 2012. http://www.cnfun.ca/LinkClick.aspx?fileticket=d4p7mZoXWDU%3d&tabid=68Canadian. Accessed 14 July 2020.

  25. Kramer MS, Platt RW, Wen SW, Joseph KS, Allen A, Abrahamowicz M, et al. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics. 2001;108:E35.

    Article  CAS  PubMed  Google Scholar 

  26. The Canadian Neonatal Network. Abstractor’s manual v.3.3.0. Toronto, Canada: The Canadian Neonatal Network; 2018. http://wwwcanadianneonatalnetworkorg/portal/CNNHome/Publicationaspx.

  27. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. 1988;82:527–32.

    Article  CAS  PubMed  Google Scholar 

  28. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529–34.

    Article  CAS  PubMed  Google Scholar 

  29. Hand IL, Shellhaas RA, Milla SS, Committee On Fetus, Newborn SONSOR. Routine neuroimaging of the preterm brain. Pediatrics 2020;146:e2020029082.

  30. Bass WT. Periventricular leukomalacia. NeoReviews. 2011;12:e76.

    Article  Google Scholar 

  31. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis - therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Gole G, Ells A, Katz X, Holmstrom G, Fielder A, Capone A, et al. The international classification of retinopathy of prematurity revisited. Arch Ophathlmology. 2005;123:991–9.

    Article  Google Scholar 

  33. Kluckow M, Lemmers P. Hemodynamic assessment of the patent ductus arteriosus: beyond ultrasound. Semin Fetal Neonatal Med. 2018;23:239–44.

    Article  CAS  PubMed  Google Scholar 

  34. Academic Press. Bayley-III clinical use and interpretation. 1st ed. Academic Press: Massachussets, USA: Academic Press; 2016.

  35. Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.

    PubMed  Google Scholar 

  36. Palisano R, Rosenbaum P, Walter S, Russell D, Wood E, Galuppi B. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol. 1997;39:214–23.

    Article  CAS  PubMed  Google Scholar 

  37. Synnes A, Luu TM, Moddemann D, Church P, Lee D, Vincer M, et al. Determinants of developmental outcomes in a very preterm Canadian cohort. Arch Dis Child Fetal Neonatal Ed. 2017;102:F235–F243.

    Article  PubMed  Google Scholar 

  38. Ounsted M, Moar VA, Scott A. Factors affecting development: similarities and differences among children who were small, average, and large for gestational age at birth. Acta Paediatr Scand. 1986;75:261–6.

    Article  CAS  PubMed  Google Scholar 

  39. Shenkin SD, Starr JM, Deary IJ. Birth weight and cognitive ability in childhood: a systematic review. Psychol Bull. 2004;130:989–1013.

    Article  PubMed  Google Scholar 

  40. Shah PS, Shah V, Qiu Z, Ohlsson A, Lee SK. Improved outcomes of outborn preterm infants if admitted to perinatal centers versus freestanding pediatric hospitals. J Pediatr. 2005;146:626–31.

    Article  PubMed  Google Scholar 

  41. Pulver LS, Guest-Warnick G, Stoddard GJ, Byington CL, Young PC. Weight for gestational age affects the mortality of late preterm infants. Pediatrics. 2009;123:e1072–1077.

    Article  PubMed  Google Scholar 

  42. Weissmann-Brenner A, Simchen MJ, Zilberberg E, Kalter A, Weisz B, Achiron R, et al. Maternal and neonatal outcomes of large for gestational age pregnancies. Acta Obstet Gynecol Scand. 2012;91:844–9.

    Article  PubMed  Google Scholar 

  43. Berger H, Gagnon R, Sermer M, Basso M, Bos H, Brown RN, et al. Diabetes in pregnancy. J Obstet Gynaecol Can. 2016;38:667–79 e661.

    Article  PubMed  Google Scholar 

  44. Boghossian NS, Hansen NI, Bell EF, Brumbaugh JE, Stoll BJ, Laptook AR, et al. Outcomes of extremely preterm infants born to insulin-dependent diabetic mothers. Pediatrics. 2016;137:e201523424.

    Article  Google Scholar 

  45. Kc K, Shakya S, Zhang H. Gestational diabetes mellitus and macrosomia: a literature review. Ann Nutr Metab. 2015;66:14–20.

    Article  CAS  PubMed  Google Scholar 

  46. Chiossi G, Pedroza C, Costantine MM, Truong VTT, Gargano G, Saade GR. Customized vs population-based growth charts to identify neonates at risk of adverse outcome: systematic review and Bayesian meta-analysis of observational studies. Ultrasound Obstet Gynecol. 2017;50:156–66.

    Article  CAS  PubMed  Google Scholar 

  47. Romero R, Tarca AL. Fetal size standards to diagnose a small- or a large-for-gestational-age fetus. Am J Obstet Gynecol. 2018;218:S605–S607.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Sjaarda LA, Albert PS, Mumford SL, Hinkle SN, Mendola P, Laughon SK. Customized large-for-gestational-age birthweight at term and the association with adverse perinatal outcomes. 2014;210:63.e1–63e.11.

  49. Hutcheon JA, Zhang X, Platt RW, Cnattingius S, Kramer MS. The case against customised birthweight standards. Paediatr Perinat Epidemiol. 2011;25:11–16.

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors thank all site investigators and data abstractors of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-Up Network (CNFUN). Full lists of Network member investigators and their affiliations appear in Supplementary Information. We thank Heather McDonald-Kinkaid, PhD, of the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada, for editorial support in preparing this manuscript; and other MiCare staff, for organizational support. MiCare is supported by the Canadian Institutes of Health Research, the Ontario Ministry of Health and Long-Term Care, and the participating hospitals.

Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program

Prakesh S. Shah6, Marc Beltempo7, Jaideep Kanungo8, Joseph Ting9, Ayman Abou Mehrem10, Jennifer Toye11, Khalid Aziz11, Jaya Bodani12, Lannae Strueby13, Mary Seshia14, Deepak Louis14, Ruben Alvaro15, Amit Mukerji16, Orlando Da Silva17, Sajit Augustine18, Kyong-Soon Lee19, Eugene Ng20, Brigitte Lemyre21, Thierry Daboval22, Faiza Khurshid23, Victoria Bizgu24, Keith Barrington25, Christine Drolet26, Bruno Piedboeuf26, Martine Claveau7, Valerie Bertelle27, Edith Masse27, Roderick Canning28, Hala Makary29, Cecil Ojah30, Luis Monterrosa30, Julie Emberley31, Jehier Afifi32, Andrzej Kajetanowicz33, Shoo K. Lee6, Thevanisha Pillay8, Anne Synnes9, Leonora Hendson34, Amber Reichert35, Matthew Hicks35, Jaya Bodani12, Cecilia de Cabo36, Chukwuma Nwaesei18, Thierry Daboval22, Linh Ly19, Edmond Kelly6, Karen Thomas16, Paige Church20, Ermelinda Pelausa24, Kim-Anh Nguyen24, May Khairy37, Marc Beltempo37, Veronique Dorval38, Thuy Mai Luu38, Charlotte Demers28, Alyssa Morin28, Sylvie Bélanger26, Roderick Canning29, Luis Monterrosa31, Hala Makary30, Phil Murphy39.

Funding

Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a Canadian Institutes of Health Research (CIHR) Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. PSS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340).

Role of the funders

The funding bodies played no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

Author information

Authors and Affiliations

  1. Section of Neonatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta, Canada

    Deepika Rustogi, Belal Alshaikh, Shabih Hasan, Prashanth Murthy & Kamran Yusuf

  2. Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada

    Anne Synnes

  3. CHU de Quebec, University of Laval, Quebec, Canada

    Christine Drolet

  4. CHU de Sherbrooke, University of Sherbrooke, Quebec, Canada

    Edith Masse

  5. Pediatrics, University of Toronto, Toronto, Canada

    Prakesh S. Shah

  6. Mount Sinai Hospital, Toronto, ON, Canada

    Prakesh S. Shah, Shoo K. Lee & Edmond Kelly

  7. Montreal Children’s Hospital at McGill University Health Centre, Montréal, QC, Canada

    Marc Beltempo & Martine Claveau

  8. Victoria General Hospital, Victoria, BC, Canada

    Jaideep Kanungo & Thevanisha Pillay

  9. British Columbia Women’s Hospital, Vancouver, BC, Canada

    Joseph Ting & Anne Synnes

  10. Foothills Medical Centre, Calgary, AB, Canada

    Ayman Abou Mehrem

  11. Royal Alexandra Hospital, Edmonton, AB, Canada

    Jennifer Toye & Khalid Aziz

  12. Regina General Hospital, Regina, SK, Canada

    Jaya Bodani

  13. Royal University Hospital, Saskatoon, SK, Canada

    Lannae Strueby

  14. Winnipeg Health Sciences Centre, Winnipeg, MB, Canada

    Mary Seshia & Deepak Louis

  15. St. Boniface General Hospital, Winnipeg, MB, Canada

    Ruben Alvaro

  16. Hamilton Health Sciences Centre, Hamilton, ON, Canada

    Amit Mukerji & Karen Thomas

  17. London Health Sciences Centre, London, ON, Canada

    Orlando Da Silva

  18. Windsor Regional Hospital, Windsor, ON, Canada

    Sajit Augustine & Chukwuma Nwaesei

  19. Hospital for Sick Children, Calgary, AB, Canada

    Kyong-Soon Lee & Linh Ly

  20. Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Eugene Ng & Paige Church

  21. The Ottawa Hospital, Ottawa, ON, Canada

    Brigitte Lemyre

  22. Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada

    Thierry Daboval

  23. Kingston General Hospital, Kingston, ON, Canada

    Faiza Khurshid

  24. Jewish General Hospital, Montréal, QC, Canada

    Victoria Bizgu, Ermelinda Pelausa & Kim-Anh Nguyen

  25. Anie Lapoint and Guillaume Ethier, Hôpital Sainte-Justine, Montréal, QC, Canada

    Keith Barrington

  26. Centre Hospitalier Universitaire de Québec, Sainte Foy, QC, Canada

    Christine Drolet, Bruno Piedboeuf & Sylvie Bélanger

  27. Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

    Valerie Bertelle & Edith Masse

  28. Moncton Hospital, Moncton, NB, Canada

    Roderick Canning, Charlotte Demers & Alyssa Morin

  29. Dr. Everett Chalmers Hospital, Fredericton, NB, Canada

    Hala Makary & Roderick Canning

  30. Saint John Regional Hospital, Saint John, NB, Canada

    Cecil Ojah, Luis Monterrosa & Hala Makary

  31. Janeway Children’s Health and Rehabilitation Centre, St. John’s, NL, Canada

    Julie Emberley & Luis Monterrosa

  32. IWK Health Centre, Halifax, NS, Canada

    Jehier Afifi

  33. Cape Breton Regional Hospital, Sydney, NS, Canada

    Andrzej Kajetanowicz

  34. Alberta’s Children’s Hospital, Foothills Medical Centre, Calgary, AB, Canada

    Leonora Hendson

  35. Glenrose Rehabilitation Hospital, Edmonton, AB, Canada

    Amber Reichert & Matthew Hicks

  36. Winnipeg Health Sciences Centre, St. Boniface General Hospital, Winnipeg, MB, Canada

    Cecilia de Cabo

  37. Montréal Children’s Hospital, Royal Victoria Hospital, Montréal, QC, Canada

    May Khairy & Marc Beltempo

  38. Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada

    Veronique Dorval & Thuy Mai Luu

  39. Charles Janeway Children’s Health and Rehabilitation Centre, St. John’s, NL, Canada

    Phil Murphy

Authors
  1. Deepika Rustogi
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  2. Anne Synnes
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  3. Belal Alshaikh
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  4. Shabih Hasan
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  5. Christine Drolet
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  6. Edith Masse
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  7. Prashanth Murthy
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  8. Prakesh S. Shah
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  9. Kamran Yusuf
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Consortia

on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program

  • Prakesh S. Shah
  • , Marc Beltempo
  • , Jaideep Kanungo
  • , Joseph Ting
  • , Ayman Abou Mehrem
  • , Jennifer Toye
  • , Khalid Aziz
  • , Jaya Bodani
  • , Lannae Strueby
  • , Mary Seshia
  • , Deepak Louis
  • , Ruben Alvaro
  • , Amit Mukerji
  • , Orlando Da Silva
  • , Sajit Augustine
  • , Kyong-Soon Lee
  • , Eugene Ng
  • , Brigitte Lemyre
  • , Thierry Daboval
  • , Faiza Khurshid
  • , Victoria Bizgu
  • , Keith Barrington
  • , Christine Drolet
  • , Bruno Piedboeuf
  • , Martine Claveau
  • , Valerie Bertelle
  • , Edith Masse
  • , Roderick Canning
  • , Hala Makary
  • , Cecil Ojah
  • , Luis Monterrosa
  • , Julie Emberley
  • , Jehier Afifi
  • , Andrzej Kajetanowicz
  • , Shoo K. Lee
  • , Thevanisha Pillay
  • , Anne Synnes
  • , Leonora Hendson
  • , Amber Reichert
  • , Matthew Hicks
  • , Jaya Bodani
  • , Cecilia de Cabo
  • , Chukwuma Nwaesei
  • , Thierry Daboval
  • , Linh Ly
  • , Edmond Kelly
  • , Karen Thomas
  • , Paige Church
  • , Ermelinda Pelausa
  • , Kim-Anh Nguyen
  • , May Khairy
  • , Marc Beltempo
  • , Veronique Dorval
  • , Thuy Mai Luu
  • , Charlotte Demers
  • , Alyssa Morin
  • , Sylvie Bélanger
  • , Roderick Canning
  • , Luis Monterrosa
  • , Hala Makary
  •  & Phil Murphy

Contributions

KY: Concept and design, supervised and revised the proposal, drafting of the manuscript, revision of the manuscript. DR: Wrote the proposal, interpreted data, drafting of manuscript, and revision of the manuscript. AS: Reviewed proposal, revision, and critical appraisal of the manuscript, acquisition of data. BA: Reviewed proposal, interpreted data, revision, and critical appraisal of the manuscript. SH: Reviewed proposal, interpreted data, revision, and critical appraisal of the manuscript. CD: Interpreted data, revision, and critical appraisal of the manuscript. EM: Interpreted data, revision, and critical appraisal of the manuscript. PM: Interpreted data, revision, and critical appraisal of the manuscript. PSS: Revision and critical appraisal of the manuscript, acquisition, and analysis of data. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work in ensuring that questions related to its accuracy or integrity are appropriately investigated and resolved.

Corresponding author

Correspondence to Kamran Yusuf.

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The authors declare no competing interests.

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Members of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program are listed below Acknowledgements.

Supplementary information

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Rustogi, D., Synnes, A., Alshaikh, B. et al. Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study. J Perinatol 41, 1313–1321 (2021). https://doi.org/10.1038/s41372-021-01080-z

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