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Short-term neurodevelopment and growth outcomes of very and moderate preterm Indian infants

Journal of Perinatology volume 42, pages 1489–1495 (2022)Cite this article

Subjects

Abstract

Objective

To study the growth and neurodevelopmental outcome of very and moderate preterm infants (VMPT) compared to term appropriate-for-age (term AGA) infants at 18-months corrected age.

Methods

This prospective cohort study enrolled consecutively born 212 VMPT infants and 250 term AGA controls delivered during study period.

Outcome measures

Major neurodevelopmental impairment (NDI) defined as any one of cerebral palsy, motor (MoDQ) or mental developmental quotient (MoDQ) <70 on Developmental Assessment Scale for Indian infants, visual or hearing impairment, or epilepsy, and growth outcomes.

Results

Among 195 VMPT and 240 term AGA infants who completed follow-up, the frequency of major NDI was 12.8% and 2.5% respectively (RR 5.1; 95% CI [2.13–12.19]). Major NDI was higher among infants <28 weeks gestation (39%) and birthweight <1000 grams (27%). A quarter of VMPT infants exhibited wasting and 18% stunting than 7% each among controls.

Conclusion

VMPT infants had a higher frequency of major NDI and growth failure at 18-months.

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Fig. 1: Study flow of very and moderate preterm (VMPT) infants and term controls from hospital discharge till 18-month neurodevelopmental assessment.
Fig. 2: Anthropometry Z score over time for very and moderate preterm infants.

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Data availability

Dataset can be requested by writing to the corresponding author.

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Acknowledgements

Ajay, Reena, Faizan, Sukhram Babu, Manju Saxena, Farha, Suresh, Nisha, Sant, Meenakshi, Anuja Aggarwala, AK Gupta, Kanak, Alok Thakkar, Garima, Sandhya.

Funding

This work was supported by the Indian Council of Medical Research (ICMR) Grant Number 5/7/305/08-RHN.

Author information

Author notes

  1. Sindhu Sivanandan

    Present address: Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

  2. Shuchita Gupta

    Present address: World Health Organization, New Delhi, India

  3. Tanushree Sahoo

    Present address: Department of Neonatology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India

  4. Chander Prakash Yadav

    Present address: National Institute of Malaria Research (NIMR), New Delhi, India

Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Sindhu Sivanandan, Shuchita Gupta, Tanushree Sahoo, Chander Prakash Yadav, Madhumati Bose, Sheffali Gulati, Savita Sapra, Sumita Gupta, M. Jeeva Sankar, Anu Thukral, Vinod K. Paul & Ramesh Agarwal

  2. Department of Ophthalmology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Rohit Saxena

  3. Department of ENT, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Kapil Sikka

  4. Department of Radiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Atin Kumar & Manisha Jana

  5. Department of Biostatistics, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Sreenivas Vishnubhatla

  6. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), India and Member, NITI Aayog, New Delhi, India

    Vinod K. Paul

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Contributions

SS and TS contributed to interpretation of data, data analysis, drafting of the manuscript, and critical revisions of the manuscript. SG conceptualized and designed the study, contributed to data collection and data analyses, and critically reviewed the manuscript. RS, KS, SG, AK, MJ coordinated and supervised data collection and critically reviewed the manuscript. SS, SG, and MB coordinated and supervised data collection. CPY and VS contributed to data analyses and critically reviewed the manuscript. AT and VKP conceptualized and designed the study and critically reviewed the manuscript. RA and MJS conceptualized and designed the study, supervised the initial analyses, reviewed and revised the manuscript.

Corresponding author

Correspondence to M. Jeeva Sankar.

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Competing interests

The authors declare no competing interests.

Ethics approval and consent to participate

The study has been approved by Institutional ethics committee of All India Institute of Medical Sciences, New Delhi (Ref: IEC/P-05/04.01.2010). Written informed consent was obtained from one or both parents prior to enrollment. The study was performed in accordance with the Declaration of Helsinki.

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Sivanandan, S., Gupta, S., Sahoo, T. et al. Short-term neurodevelopment and growth outcomes of very and moderate preterm Indian infants. J Perinatol 42, 1489–1495 (2022). https://doi.org/10.1038/s41372-022-01519-x

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