In a study of 23 patients with juvenile dermatomyositis (JDM), multivariate analysis of 26 histopathological parameters identified two distinct subgroups, with one cluster of patients (n = 11) having more severe disease and a higher frequency of antibodies against nuclear matrix protein 2 (NXP2) than the other cluster (n = 12). Patients with anti-NXP2 antibodies also required more aggressive treatment and had a lower rate of remission than patients with other or no myositis-specific antibodies.
References
Aouizerate, J. et al. Muscle ischaemia associated with NXP2 autoantibodies: a severe subtype of juvenile dermatomyositis. Rheumatology https://doi.org/10.1093/rheumatology/kex516 (2018)
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Onuora, S. Anti-NXP2 antibodies associated with severe JDM. Nat Rev Rheumatol 14, 248 (2018). https://doi.org/10.1038/nrrheum.2018.46
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DOI: https://doi.org/10.1038/nrrheum.2018.46
