In general, an inverse relationship between smoking and BMI exists
Post-cessation-related obesity might contribute to insulin resistance
The number one reason for not wanting to quit smoking or quitting and then relapsing is fear of post-cessation weight gain, especially in women and in individuals with obesity
Future smoking cessation programs and therapies need to be designed with an emphasis on reducing post-cessation weight gain
The benefits of smoking cessation outweigh the risks
Smoking continues to be the leading cause of preventable death in the USA, despite the vast and widely publicized knowledge about the negative health effects of tobacco smoking. Data show that smoking cessation is often accompanied by weight gain and an improvement in insulin sensitivity over time. However, paradoxically, post-cessation-related obesity might contribute to insulin resistance. Furthermore, post-cessation weight gain is reportedly the number one reason why smokers, especially women, fail to initiate smoking cessation or relapse after initiating smoking cessation. In this Review, we discuss the metabolic effects of stopping smoking and highlight future considerations for smoking cessation programs and therapies to be designed with an emphasis on reducing post-cessation weight gain.
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Salary support for T.C.F. was provided by the Diversity-promoting Institutions Drug Abuse Research Development Program (grant R24DA017298) and the National Institute on Minority Health and Health Disparities (grant U54MD007598). The authors acknowledge the professional development core of the Charles R. Drew University Accelerating Excellence in Translational Science (AXIS) (grant U54MD007598) for help with editing the manuscript.
The authors declare no competing financial interests.
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Harris, K., Zopey, M. & Friedman, T. Metabolic effects of smoking cessation. Nat Rev Endocrinol 12, 299–308 (2016). https://doi.org/10.1038/nrendo.2016.32
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