Reproductive endocrinology

Paracetamol-induced endocrine disruption in human fetal testes

Paracetamol is the most frequently used medication during pregnancy. Among concerns about its prenatal use, the association with failure of the testes to descend in neonates is the latest. A new study investigating the origin of this malformation reports that paracetamol can reduce testosterone levels in host mice transplanted with human fetal testis tissue.

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Figure 1: Phases of testicular descent and their regulation.


  1. 1

    Werler, M. M., Mitchell, A. A., Hernandez-Diaz, S. & Honein, M. A. Use of over-the-counter medications during pregnancy. Am. J. Obstet. Gynecol. 193, 771–777 (2005).

    Article  Google Scholar 

  2. 2

    Kristensen, D. M. et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum. Reprod. 26, 235–244 (2011).

    CAS  Article  Google Scholar 

  3. 3

    Snijder, C. A. et al. Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study. Hum. Reprod. 27, 1191–1201 (2012).

    Article  Google Scholar 

  4. 4

    Burdan, F. et al. Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. Pharmacol. Rep. 64, 521–527 (2012).

    CAS  Article  Google Scholar 

  5. 5

    Jensen, M. S. et al. Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Epidemiology 21, 779–785 (2010).

    Article  Google Scholar 

  6. 6

    Virtanen, H. E. & Toppari, J. Epidemiology and pathogenesis of cryptorchidism. Hum. Reprod. Update 14, 49–58 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Hutson, J. M., Li, R., Southwell, B. R., Newgreen, D. & Cousinery, M. Regulation of testicular descent. Pediatr. Surg. Int. 31, 317–325 (2015).

    Article  Google Scholar 

  8. 8

    van den Driesche, S. et al. Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model. Sci. Transl. Med. 7, 288ra80 (2015).

    Article  Google Scholar 

  9. 9

    Kristensen, D. M. et al. Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. Int. J. Androl. 35, 377–384 (2012).

    CAS  Article  Google Scholar 

  10. 10

    Mazaud-Guittot, S. et al. Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent. J. Clin. Endocrinol. Metab. 98, E1757–E1767 (2013).

    CAS  Article  Google Scholar 

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B.J. acknowledges funding support from the Agence Nationale de Sécurité du Medicament (ANSM, grant no. AAP-2012-037), the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Rennes 1 and the Ecole des Hautes Études en Santé Publique (EHESP – School of Public Health).

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Correspondence to Bernard Jégou.

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Jégou, B. Paracetamol-induced endocrine disruption in human fetal testes. Nat Rev Endocrinol 11, 453–454 (2015).

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