Gonadal disorders articles from across Nature Portfolio

A study based on in vivo and in vitro experiments suggests that FTO enhances GnRH expression, which promotes puberty onset, by regulating m6A demethylation of PLCβ3 and activating the Ca²⁺ signalling pathway.

In this Expert Recommendation, the authors provide a standardized nomenclature to improve the Human Phenotype Ontology tree with regard to the classification of non-syndromic male infertility. The implications of introducing this vocabulary in promoting communication across disciplines and institutions and in discovering novel genetic causes of non-syndromic male infertility are also discussed.

Up to one in four women with type 1 diabetes mellitus (T1DM) also have polycystic ovary syndrome (PCOS). Under subcutaneous insulin administration, systemic hyperinsulinism might trigger PCOS in women predisposed to the condition. However, very little is known about the long-term consequences of androgen excess in women with T1DM, and management guidelines are lacking.

A new Consensus Statement calls for precautionary action around the use of paracetamol in pregnancy, through focused research efforts and by increasing awareness.