Sibling rivalry in the E2F family. Trimarchi, J. M. & Lees, J. A. Nature Reviews Molecular Cell Biology January (2002) Nature Reviews Molecular Cell Biology

Mechanisms of transcription-coupled DNA repair. Svejstrup, J. Q. Nature Reviews Molecular Cell Biology January (2002) Nature Reviews Molecular Cell Biology

MAPK-regulated transcription: a continuously variable gene switch? Hazzalin C. A. & Mahadevan, L. C. Nature Reviews Molecular Cell Biology January (2002) Nature Reviews Molecular Cell Biology

Transforming growth factor-β in T-cell biology. Gorelik, L. & Flavell, R. A. Nature Reviews Immunology January (2002) Nature Reviews Immunology

Tumor-specific mutations in p53: the acid test. Hainault, P. Nature Medicine January (2002) Nature Medicine

This News and Views article discusses the significance of the p53 R337H tumour-specific 'signature' mutation found in childhood adrenal cortical carcinomas. The underlying molecular defect is described by DiGammarino et al . in the January issue of Nature Structural Biology.

Hedgehog signalling and brain morphogenesis. Ruizi Altaba, A., Palma, V. & Dahmane, N. Nature Reviews Neuroscience January (2002) Nature Reviews Neuroscience

Novel effector function for an old receptor. Klein, R. Nature Cell Biology January (2002) Nature Cell Biology

This News and Views article discusses how the β4-integrin subunit enhances invasive growth by acting as an effector for the Met receptor.

The microarray way to tailored cancer treatment. Van't Veer, L. J. & De Jong, D. Nature Medicine January (2002) Nature Medicine

This News and Views article describes how diffuse large B-cell lymphomas can be classified following microarray expression analysis. The results of this might affect treatment options.

Lymphatic endothelium: a new frontier of metastasis research. Karkkainen, M. J., Mäkinen, T. & Alitalo, K. Nature Cell Biology January (2002) Nature Cell Biology

With the identification of specific growth factors and cell-surface markers for lymphatic endothelial cells, their importance in angiogenesis and metastasis is becoming clearer, as discussed in this commentary.