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Zooming in on AMPA receptor regulation by CaMKII

Nature Neuroscience volume 14, pages 674–675 (2011)Cite this article

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Insights into the molecular mechanism of synaptic plasticity suggest that AMPA receptor phosphorylation by CaMKII accelerates channel opening and that TARPs preserve this regulation despite the presence of a GluA2 subunit.

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Figure 1: CaMKII increases the conductance of the AMPA receptor by enhancing closed-to-open state coupling (gating) of individual GluA1 subunits and TARPs preserve this regulation despite the presence of the GluA2 subunit.

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  1. The author is at the Vollum Institute, Oregon Health & Science University, Portland, Oregon, USA.,

    Victor Derkach

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  1. Victor Derkach
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Correspondence to Victor Derkach.

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Derkach, V. Zooming in on AMPA receptor regulation by CaMKII. Nat Neurosci 14, 674–675 (2011). https://doi.org/10.1038/nn.2852

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