Many HIV-infected people show impaired humoral immune responses, but it is unclear why. A new view into this conundrum may be provided with the recent discovery of altered interactions between follicular helper T (TFH) cells and germinal center B cells from HIV-infected individuals. This leads to inadequate TFH cell help for germinal center B cells and decreased B cell antibody responses (pages 494–499).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Divergent Primary Immune Responses Induced by Human Immunodeficiency Virus-1 gp120 and Hepatitis B Surface Antigen Determine Antibody Recall Responses
Virologica Sinica Open Access 14 December 2018
-
Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
Retrovirology Open Access 08 February 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
De Milito, A., Morch, C., Sonnerborg, A. & Chiodi, F. AIDS 15, 957–964 (2001).
Moir, S. & Fauci, A.S. Nat. Rev. Immunol. 9, 235–245 (2009).
Lindqvist, M. et al. J. Clin. Invest. 122, 3271–3280 (2012).
Petrovas, C. et al. J. Clin. Invest. 122, 3281–3294 (2012).
Vinuesa, C.G. J. Clin. Invest. 122, 3059–3062 (2012).
Perreau, M. et al. J. Exp. Med. 210, 143–156 (2013).
Cubas, R.A. et al. Nat. Med. 19, 494–499 (2013).
Lee, S.J. et al. FEBS Lett. 580, 755–762 (2006).
Sage, P.T., Francisco, L.M., Carman, C.V. & Sharpe, A.H. Nat. Immunol. 14, 152–161 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Pillai, S. Love the one you're with: the HIV, B cell and TFH cell triangle. Nat Med 19, 401–402 (2013). https://doi.org/10.1038/nm.3141
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3141
This article is cited by
-
Divergent Primary Immune Responses Induced by Human Immunodeficiency Virus-1 gp120 and Hepatitis B Surface Antigen Determine Antibody Recall Responses
Virologica Sinica (2018)
-
PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas
Nature Reviews Clinical Oncology (2017)
-
Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
Retrovirology (2015)