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Serine-threonine kinases in TCR signaling

Nature Immunology volume 15, pages 808–814 (2014)Cite this article

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Abstract

T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Here we explore how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism to meet the metabolic demands of participating in an immune response.

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Figure 1: DAG-regulated serine-threonine kinases in T cells.
Figure 2: Ras-regulated serine-threonine kinase pathways.
Figure 3: The PtdIns(3,4,5)P3-regulated serine-threonine kinase Akt.
Figure 4: Nutrient-sensing serine-threonine kinases in T cells.

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  1. Instituto Investigación Sanitaria/Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain

    María N Navarro

  2. Division of Cell Signalling and Immunology, The College of Life Sciences, University of Dundee, Dundee, UK

    Doreen A Cantrell

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Navarro, M., Cantrell, D. Serine-threonine kinases in TCR signaling. Nat Immunol 15, 808–814 (2014). https://doi.org/10.1038/ni.2941

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