Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Is there an increased risk of hip fracture in patients on long-term PPI therapy?

Nature Clinical Practice Gastroenterology & Hepatology volume 4, pages 420–421 (2007)Cite this article

boxed-textYang Y et al. (2006) Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 296: 2947–2953

Background

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Thorens J et al. (1996) Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 39: 54–59

    Article  CAS  Google Scholar 

  2. Raghunath AS et al. (2005) Review article: the long-term use of proton-pump inhibitors. Aliment Pharmacol Ther 22: 55–63

    Article  CAS  Google Scholar 

  3. Boutet RM et al. (1999) Survey on repeat prescribing for acid suppression drugs in primary care in Cornwall and the Isles of Scilly. Aliment Pharmacol Ther 13: 813–817

    Article  CAS  Google Scholar 

  4. Jalving M et al. (2006) Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther 24: 1341–1348

    Article  CAS  Google Scholar 

  5. Bateman DN et al. (2003) Mortality study of 18,000 patients treated with omeprazole. Gut 52: 942–946

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

  1. NJ Talley is a Professor of Medicine, HK Jung and X Jiang are Gastrointestinal Research Fellows and GR Locke is a Professor of Medicine at the Mayo Clinic, Rochester, MN, USA.,

    Nicholas J Talley, Hye Kyung Jung, Xuan Jiang & G Richard Locke

Authors
  1. Nicholas J Talley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hye Kyung Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuan Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Richard Locke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nicholas J Talley.

Ethics declarations

Competing interests

Dr Talley has consulted for AstraZeneca and received research support from TAP. Dr Locke has received research support from TAP.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Talley, N., Jung, H., Jiang, X. et al. Is there an increased risk of hip fracture in patients on long-term PPI therapy?. Nat Rev Gastroenterol Hepatol 4, 420–421 (2007). https://doi.org/10.1038/ncpgasthep0870

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpgasthep0870

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing