Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy

Nature Clinical Practice Endocrinology & Metabolism volume 3, pages 740–741 (2007)Cite this article

boxed-textLaurberg P et al. (2007) Sources of circulating 3,5,3′-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases. J Clin Endocrinol Metab 92: 2149–2156

Background

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bianco AC et al. (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23: 38–89

    Article  CAS  PubMed  Google Scholar 

  2. Maia AL et al. (2005) Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 115: 2524–2533

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Abuid J and Larsen PR (1974) Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. J Clin Invest 54: 201–208

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cooper DS (2005) Antithyroid drugs. N Engl J Med 352: 905–917

    Article  CAS  PubMed  Google Scholar 

  5. Nakamura H (2007) Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab 92: 2157–2162

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Vicky Heath, Associate Editor, Nature Clinical Practice.

Author information

Author notes

  1. Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, RS 90035-003, Brazil almaia@ufrgs.br

Authors and Affiliations

  1. Endocrine Division, AL Maia is an Associate Professor of Medicine and Chief of the Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.,

    Ana Luiza Maia

Authors
  1. Ana Luiza Maia
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maia, A. Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy. Nat Rev Endocrinol 3, 740–741 (2007). https://doi.org/10.1038/ncpendmet0619

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpendmet0619

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing