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Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo

Nature Cell Biology volume 4, pages E203–E206 (2002)Cite this article

Abstract

Protein–protein interactions contribute to the spatial and temporal resolution of many signal transduction cascades. Here, we discuss recent advances in our understanding of phosphatase-targeting subunits, kinase-anchoring proteins and the multiprotein signalling networks that they assemble.

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Figure 1: Type-1 phosphatase-targeting subunits.
Figure 2: PKC-interacting proteins.
Figure 3: A-kinase-anchoring proteins.

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Acknowledgements

The authors wish to thank T. Hunter, T. Pawson and members of the Scott lab for critical evaluation of this article, and D. Lin and T. Pawson for kindly providing the image used as the background to Fig. 2b. J.D.S. is supported in part by the National Institutes of Health, grant GM48231.

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  1. Howard Hughes Medical Institute, Vollum Institute, Oregon Health & Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, 97201-3098, OR, USA

    Andrea L. Bauman & John D. Scott

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Correspondence to John D. Scott.

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Bauman, A., Scott, J. Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo. Nat Cell Biol 4, E203–E206 (2002). https://doi.org/10.1038/ncb0802-e203

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