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Skp2: caught in the Akt

Nature Cell Biology volume 11, pages 377379 (2009) | Download Citation

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To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt — a major kinase that coordinates diverse signalling pathways — phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.

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Author information

Affiliations

  1. Karin Ecker and Ludger Hengst are in the Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck Austria.  ludger.hengst@i-med.ac.

    • Karin Ecker
    •  & Ludger Hengst

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DOI

https://doi.org/10.1038/ncb0409-377

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